Title:
POLYAMIDE NUCLEIC ACID DERIVATIVES, AGENTS AND METHODS FOR PRODUCING THEM
Document Type and Number:
WIPO Patent Application WO2001079216
Kind Code:
A3
Abstract:
The invention relates to PNA derivatives that carry one or more phosphoryl groups at the C terminus or at the C and N terminus of the PNA backbone, said phosphoryl groups optionally carrying one or more marker groups, or groups for cross-linking, or groups that promote the intracellular uptake, or groups that improve the binding affinity of the PNA derivative to nucleic acids. The invention further relates to a method for producing the above PNA derivatives and to the use thereof as a medicament or diagnostic agent.
Inventors:
UHLMANN EUGEN
BREIPOHL GERHARD
WILL DAVID WILLIAM
BREIPOHL GERHARD
WILL DAVID WILLIAM
Application Number:
PCT/EP2001/004030
Publication Date:
February 28, 2002
Filing Date:
April 07, 2001
Export Citation:
Assignee:
AVENTIS PHARMA GMBH (DE)
International Classes:
G01N33/53; A61K38/00; A61K48/00; A61P11/06; A61P17/00; A61P17/06; A61P31/16; A61P31/18; A61P35/00; C07K14/00; C08G69/48; C12Q1/04; C12Q1/68; G01N21/78; G01N33/566; G01N33/58; (IPC1-7): C07K14/00; C12Q1/68; C07F9/40
Domestic Patent References:
| WO1999037670A1 | 1999-07-29 | |||
| WO1999033867A2 | 1999-07-08 | |||
| WO1996011205A1 | 1996-04-18 |
Foreign References:
| US5874553A | 1999-02-23 | |||
| EP0672677A2 | 1995-09-20 | |||
| DE19508923A1 | 1996-09-19 | |||
| DE19640974A1 | 1998-04-16 |
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