Title:
POLYAMINE ANALOGUES AS THERAPEUTIC AND DIAGNOSTIC AGENTS
Document Type and Number:
WIPO Patent Application WO2001092218
Kind Code:
A3
Abstract:
Novel "bispolyamine" inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. These compounds display desirable activities both for diagnostic and research assays and therapy.
Inventors:
VERMEULIN NICOLAAS M J (US)
O'DAY CHRISTINE L (US)
WEBB HEATHER K (US)
BURNS MARK R (US)
BERGSTROM DONALD E (US)
O'DAY CHRISTINE L (US)
WEBB HEATHER K (US)
BURNS MARK R (US)
BERGSTROM DONALD E (US)
Application Number:
PCT/US2001/017795
Publication Date:
March 27, 2003
Filing Date:
May 31, 2001
Export Citation:
Assignee:
ORIDIGM CORP (US)
International Classes:
A61K31/16; A61K31/165; A61K31/166; A61K31/17; A61K31/18; A61K31/185; A61K31/197; A61K31/198; A61K31/27; A61K31/277; A61K31/341; A61K31/381; C07D233/90; A61K31/401; A61K31/405; A61K31/415; A61K31/42; A61K31/427; A61K31/433; A61K31/44; A61K31/4436; A61K31/47; A61K31/473; A61K31/506; A61K47/48; A61P1/12; A61P9/10; A61P9/12; A61P17/06; A61P19/10; A61P25/00; A61P25/08; A61P25/18; A61P25/24; A61P25/28; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P37/02; A61P43/00; C07C211/13; C07C211/52; C07C211/54; C07C233/36; C07C233/39; C07C233/40; C07C233/62; C07C233/63; C07C233/78; C07C235/20; C07C235/34; C07C235/50; C07C235/74; C07C237/10; C07C237/20; C07C237/22; C07C237/42; C07C239/16; C07C271/20; C07C271/22; C07C275/28; C07C275/40; C07C279/14; C07C311/05; C07C311/06; C07C311/10; C07C311/14; C07C311/18; C07C311/19; C07C311/24; C07C311/29; C07C311/41; C07C311/42; C07C311/44; C07C323/60; C07C327/42; C07D207/16; C07D209/20; C07D209/22; C07D213/81; C07D213/82; C07D215/36; C07D215/52; C07D219/04; C07D231/14; C07D233/84; C07D261/18; C07D285/14; C07D285/22; C07D307/68; C07D307/91; C07D333/24; C07D333/34; C07D333/38; C07D401/04; C07D409/04; C07D409/12; C07D417/04; C07F9/645; G01N33/53; (IPC1-7): C07C311/18; C07C233/36; C07C233/37; C07C271/10; C07C311/41; C07C311/11; C07D307/77; C07D333/34; C07D409/04; A61K31/165; A61K31/18; A61K31/33
Domestic Patent References:
| WO1999003823A2 | 1999-01-28 | |||
| WO1999054283A1 | 1999-10-28 |
Foreign References:
| EP1085011A1 | 2001-03-21 |
Other References:
G.J. ATWELL ET AL, J. MED. CHEM., vol. 29, no. 1, 1986, pages 69 - 74, XP000891842
G. SOSNOVSKY ET AL, Z. NATURFORSCH., B: CHEM. SCI., vol. 49, no. 11, 1994, pages 1580 - 1585, XP001040443
C. Q. XIA ET AL, J. DRUG TARGETING, vol. 6, no. 1, 1998, pages 65 - 77, XP001040438
M. K.-H. DOLL ET AL, HELV. CHIM. ACTA, vol. 79, no. 2, 1996, pages 541 - 547, XP001040442
G. SOSNOVSKY ET AL, Z. NATURFORSCH., B: CHEM. SCI., vol. 49, no. 11, 1994, pages 1580 - 1585, XP001040443
C. Q. XIA ET AL, J. DRUG TARGETING, vol. 6, no. 1, 1998, pages 65 - 77, XP001040438
M. K.-H. DOLL ET AL, HELV. CHIM. ACTA, vol. 79, no. 2, 1996, pages 541 - 547, XP001040442
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