Title:
POLYCYCLIC KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/148354
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of medicine, and specifically relates to a polycyclic DNA-PK inhibitor compound as represented by general formula (I), a pharmaceutically acceptable salt thereof or an isomer thereof; a pharmaceutical composition and preparation which contain the compound, the pharmaceutically acceptable salt thereof or the isomer thereof; a method for preparing the compound, the pharmaceutically acceptable salt thereof or the isomer thereof; and the use of the compound, the pharmaceutically acceptable salt thereof or the isomer thereof.
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Inventors:
LIU BIN (CN)
CHEN BO (CN)
LIU YUESHENG (CN)
MA KELIN (CN)
CHEN BO (CN)
LIU YUESHENG (CN)
MA KELIN (CN)
Application Number:
PCT/CN2022/070195
Publication Date:
July 14, 2022
Filing Date:
January 05, 2022
Export Citation:
Assignee:
SHANDONG XUANZHU PHARMA CO LTD (CN)
XUANZHU BIOPHARMACEUTICAL CO LTD (CN)
XUANZHU BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D519/00; A61K31/519; A61K31/527; A61P35/00
Domestic Patent References:
| WO2020238900A1 | 2020-12-03 | |||
| WO2006126010A2 | 2006-11-30 | |||
| WO2021098813A1 | 2021-05-27 | |||
| WO2021213460A1 | 2021-10-28 |
Foreign References:
| CN111757876A | 2020-10-09 | |||
| CN101754964A | 2010-06-23 |
Other References:
MARIA DEL CARMEN RUIZ RUIZ; ANDREA VASELLA: "The ‘t‐Amino Effect’ of ortho‐Nitroso Amines. Synthesis of 2,6‐Diaminoadenine Derivatives from 6‐(Dialkylamino)‐5‐nitrosopyrimidines", HELVETICA CHIMICA ACTA, vol. 94, no. 5, 10 May 2011 (2011-05-10), Hoboken, USA, pages 785 - 800, XP071270373, ISSN: 0018-019X, DOI: 10.1002/hlca.201100098
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