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Title:
POLYCYCLIC PYRIDONE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143424
Kind Code:
A1
Abstract:
Provided are a polycyclic pyridone derivative, a pharmaceutical composition and the use thereof. The polycyclic pyridone derivative is a compound as shown in formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt of the compound as shown in formula (I), or a prodrug thereof. Compared with existing compounds of the same class, the compound can not only inhibit the replication of the influenza virus well, but also has a lower cytotoxicity.

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Inventors:
JIANG YUYANG (CN)
TANG LIN (CN)
ZHANG CUNLONG (CN)
WU WEIBIN (CN)
LI ANQI (CN)
CHEN DAWEI (CN)
Application Number:
PCT/CN2021/140943
Publication Date:
July 07, 2022
Filing Date:
December 23, 2021
Export Citation:
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Assignee:
SHENZHEN KIVITA INNOVATIVE DRUG INST (CN)
International Classes:
A61K31/5365; C07D498/14; A61P31/16
Domestic Patent References:
WO2020004443A12020-01-02
Foreign References:
CN112724156A2021-04-30
CN109721615A2019-05-07
CN107709321A2018-02-16
CN103228653A2013-07-31
Other References:
TANG LIN, YAN HAIYAN, WU WEIBIN, CHEN DAWEI, GAO ZHENXIONG, HOU JINQIANG, ZHANG CUNLONG, JIANG YUYANG: "Synthesis and Anti-Influenza Virus Effects of Novel Substituted Polycyclic Pyridone Derivatives Modified from Baloxavir", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, no. 19, 14 October 2021 (2021-10-14), US , pages 14465 - 14476, XP055947752, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c00979
Attorney, Agent or Firm:
BEIJING SICHUANG DACHENG INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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