Title:
POLYENE ANTIBIOTICS, COMPOSITIONS CONTAINING SAID ANTIBIOTICS, METHOD AND MICRO-ORGANISMS USED TO OBTAIN SAME AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO2006100330
Kind Code:
A3
Abstract:
The invention relates to novel polyenes having formula (I), wherein: R1 represents alkyl, C1-C3; and R2 represents a functional group selected from CH3- or CONH2- (methyl or primary amide). The aforementioned polyenes have a biocide action on organisms comprising cell membranes that contain ergosterol, e.g. fungi or parasites. Said compounds can be obtained using a method that consists in cultivating a producing micro-organism under conditions that enable the production thereof. In addition, the invention also relates to a mechanism for the in vitro production of amidated polyenes, consisting in incubating carboxylated polyenes with cell-free extracts (or proteinaceous fractions) of the producers of same in the presence of ATP/Mg++ and an amide-group donor compound (preferably glutamine).
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Inventors:
MALPARTIDA ROMERO FRANCISCO (ES)
SECO MARTIN ELENA MARIA (ES)
CUESTA VELASCO TRINIDAD (ES)
SECO MARTIN ELENA MARIA (ES)
CUESTA VELASCO TRINIDAD (ES)
Application Number:
PCT/ES2006/000142
Publication Date:
November 23, 2006
Filing Date:
March 23, 2006
Export Citation:
Assignee:
CONSEJO SUPERIOR INVESTIGACION (ES)
MALPARTIDA ROMERO FRANCISCO (ES)
SECO MARTIN ELENA MARIA (ES)
CUESTA VELASCO TRINIDAD (ES)
MALPARTIDA ROMERO FRANCISCO (ES)
SECO MARTIN ELENA MARIA (ES)
CUESTA VELASCO TRINIDAD (ES)
International Classes:
C07H17/08; A61P31/00; C12P19/62; C12R1/465
Foreign References:
| US4783527A | 1988-11-08 | |||
| US4365058A | 1982-12-21 |
Other References:
PANDEY R.C. AND RINEHART K.L.: "Polyene antibiotics. VIII. The structure of rimocidin", THE JOURNAL OF ANTIBIOTICS, vol. 30, no. 2, 1977, pages 146 - 157, XP008072582
SECO E.M. ET AL.: "Starter unit choice determines the production of two tetraene macrolides, rimocidin and CE-108. in Streptomyces diastaticus var. 108", CHEMISTRY OF BIOLOGY, vol. 11, no. 3, March 2004 (2004-03-01), pages 357 - 366, XP003003691
BYRNE B. ET AL.: "Biosynthesis of deoxyamphotericines and deoxyamphoteronolides by engineered strains of Streptomyces nodosus", CHEMISTRY AND BIOLOGY, vol. 10, no. 12, December 2003 (2003-12-01), pages 1215 - 1224, XP003003692
CAFFREY P. ET AL.: "Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes", CHEMISTRY AND BIOLOGY, vol. 8, no. 7, July 2001 (2001-07-01), pages 713 - 723, XP002297623
SECO E.M. ET AL.: "Starter unit choice determines the production of two tetraene macrolides, rimocidin and CE-108. in Streptomyces diastaticus var. 108", CHEMISTRY OF BIOLOGY, vol. 11, no. 3, March 2004 (2004-03-01), pages 357 - 366, XP003003691
BYRNE B. ET AL.: "Biosynthesis of deoxyamphotericines and deoxyamphoteronolides by engineered strains of Streptomyces nodosus", CHEMISTRY AND BIOLOGY, vol. 10, no. 12, December 2003 (2003-12-01), pages 1215 - 1224, XP003003692
CAFFREY P. ET AL.: "Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes", CHEMISTRY AND BIOLOGY, vol. 8, no. 7, July 2001 (2001-07-01), pages 713 - 723, XP002297623
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