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Title:
POLYHYDROXYLATED PYRROLIZIDINE
Document Type and Number:
WIPO Patent Application WO2004064715
Kind Code:
A3
Abstract:
Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula (I), wherein R is selected from the group comprising hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups, or a pharmaceutically acceptable salt or derivative thereof, are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, haemorestoration, alleviation of immunosuppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells.

Inventors:
WATSON ALISON ANN (GB)
NASH ROBERT JAMES (GB)
EVINSON EMMA LOUISA (GB)
Application Number:
PCT/GB2004/000198
Publication Date:
December 23, 2004
Filing Date:
January 21, 2004
Export Citation:
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Assignee:
MOLECULARNATURE LTD (GB)
WATSON ALISON ANN (GB)
NASH ROBERT JAMES (GB)
EVINSON EMMA LOUISA (GB)
International Classes:
A61K31/40; A61K31/407; A61K31/7028; A61K36/185; A61K36/61; A61K45/06; A61P31/00; A61P35/00; C07D487/04; C07H3/02; C07H17/02; (IPC1-7): C07D487/04; A61P31/00; A61P35/00; A61K31/40; C07H3/02
Other References:
BELL A A ET AL: "Synthesis of Casuarines [Pentahydroxylated Pyrrolizidines] by Sodium Hydrogen Telluride-Induced Cyclisations of Azidodimesylates", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 38, no. 33, 18 August 1997 (1997-08-18), pages 5869 - 5872, XP004085896, ISSN: 0040-4039
WORMALD M R ET AL: "Configurational and conformational analysis of highly oxygenated pyrrolizidines: definitive identification of some naturally occurring 7a-epi-alexines", TETRAHEDRON: ASYMMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 9, no. 14, 17 July 1998 (1998-07-17), pages 2549 - 2558, XP004131419, ISSN: 0957-4166
NASH ET AL.: "Casuarine: A very Highly Oxygenated Pyrrolizidine Alkaloid", TETRAHEDRON LETTERS, vol. 35, no. 42, 1994, pages 7849 - 7852, XP002274756
DENMARK ET AL.: "Synthesis of (+)-Casuarine", ORGANIC LETTERS, vol. 1, no. 8, 1999, pages 1311 - 1314, XP002274757
DENMARK ET AL.: "Synthesis of (+)-Casuarine", J. ORG. CHEM., vol. 62, 2000, pages 2875 - 2886, XP002274758
WORMALD M R ET AL.: "Casuarine-6-alpha-D-Glucoside from Casuarina Equisetifolia and Eugenia Jambolana", CARBOHYDRATE LETTERS, vol. 2, no. 3, 1996, pages 169 - 174, XP009028337, ISSN: 1073-5070
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