POLYKETIDES AND THEIR SYNTHESIS

Title:

POLYKETIDES AND THEIR SYNTHESIS

Document Type and Number:

WIPO Patent Application WO2000000500

Kind Code:

A3

Abstract:

A polyketide synthase ("PKS") of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. Ths first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.

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Inventors:

LEADLAY PETER FRANCIS (GB)
STAUNTON JAMES (GB)
CORTES JESUS (GB)
MCARTHUR HAMISH ALASTAIR IRVIN (US)

Application Number:

PCT/GB1999/002042

Publication Date:

March 16, 2000

Filing Date:

June 29, 1999

Export Citation:

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Assignee:

BIOTICA TECH LTD (GB)
PFIZER (US)
LEADLAY PETER FRANCIS (GB)
STAUNTON JAMES (GB)
CORTES JESUS (GB)
MCARTHUR HAMISH ALASTAIR IRVIN (US)

International Classes:

A01K67/027; A61K31/7042; A01H5/00; A61K31/7048; A61P31/04; C07H17/08; C07K19/00; C12N5/10; C12N9/10; C12N11/18; C12N15/00; C12N15/09; C12N15/52; C12P17/06; C12P17/08; C12P19/62; (IPC1-7): C07H17/08; A61K31/70

Domestic Patent References:

WO1991016334A1	1991-10-31
WO1998001546A2	1998-01-15
WO1998001571A2	1998-01-15
WO1995008548A1	1995-03-30
WO1998049315A2	1998-11-05
WO1999035157A1	1999-07-15

Other References:

L.LIN ET AL.: "Biosynthesis of 2-Nor-6-deoxyerythronolide B by Rationally Designed Domain Substitution.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 119, no. 43, 29 October 1997 (1997-10-29), AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 10553 - 10554, XP002121612, ISSN: 0002-7863

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