Title:
POLYKETIDES AND THEIR SYNTHESIS
Document Type and Number:
WIPO Patent Application WO2005054265
Kind Code:
A3
Abstract:
Macrolides particularly erythromycins and azithromycins, having O-mycaminosyl or O-angolosaminyl groups, particularly at the 5-position, are produced using a gene cassette comprising a combination of genes which, in an appropriate strain background, are able to direct the synthesis of mycaminose or angolosamine and to direct its subsequent transfer to an aglycone or pseudoaglycone. Synthetic genes may comprise one or more of angMIII, angMI, angB, angAI, angAII, angorf14, angorf4, tylMIII, tylMI, tylB, tylAI, tylAII, eryCVI, spnO, eryBVI, eryK, tyl Ia and ery G. Glycosyltransfer genes may comprise one or more of eryCIII, tylMII, angMII, desVII, eryBV, spnP and midI
Inventors:
GAISSER SABINE (GB)
Application Number:
PCT/GB2004/005001
Publication Date:
August 25, 2005
Filing Date:
November 29, 2004
Export Citation:
Assignee:
BIOTICA TECH LTD (GB)
PFIZER (US)
GAISSER SABINE (GB)
PFIZER (US)
GAISSER SABINE (GB)
International Classes:
C07H17/08; C12N9/10; C12N15/52; C12P19/60; C12P19/62; (IPC1-7): C12P19/62; C07H17/08; C12N15/52; C12P19/60
Domestic Patent References:
| WO2001079520A1 | 2001-10-25 | |||
| WO1999005283A2 | 1999-02-04 |
Foreign References:
| US3598805A | 1971-08-10 | |||
| EP1024145A2 | 2000-08-02 | |||
| US6521406B1 | 2003-02-18 |
Other References:
M. SUZUKI ET AL.: "Biological glycosidation of macrolide aglycones I. Isolation and characterization of 5-O-mycaminosyl narbonolide and 9-dihydro-5-O-mycaminosyl narbonolide", J. ANTIBIOT., vol. XXIX, 1976, pages 1203 - 1208, XP009045970
S. RENGARAJU ET AL., SCI. REPORTS OF MEIJI SEIKA KAISHA, vol. 24, 1985, pages 52 - 54, XP009045973
P.H. JONES ET AL.: "Chemical modifications of erythromycin antibiotics II. Synthesis of 4'-hydroxyerythromycin A", ANTIMICROB. AGENTS CHEMOTHER., 1969, pages 123 - 130, XP009045968
L. ZHAO ET AL.: "Engineering a methymycin/ pikromycin-calicheamicin hybrid: two new macrolides carrying a designed sugar moiety", J. AM. CHEM. SOC., vol. 121, 1999, pages 9881 - 9882, XP002210927
N. BATE ET AL.: "Thy mycarose biosynthetic genes of Streptomyces fradiae, producer of tylosin", MICROBIOLOGY, vol. 146, 2000, pages 139 - 146, XP002284343
S. RENGARAJU ET AL., SCI. REPORTS OF MEIJI SEIKA KAISHA, vol. 24, 1985, pages 52 - 54, XP009045973
P.H. JONES ET AL.: "Chemical modifications of erythromycin antibiotics II. Synthesis of 4'-hydroxyerythromycin A", ANTIMICROB. AGENTS CHEMOTHER., 1969, pages 123 - 130, XP009045968
L. ZHAO ET AL.: "Engineering a methymycin/ pikromycin-calicheamicin hybrid: two new macrolides carrying a designed sugar moiety", J. AM. CHEM. SOC., vol. 121, 1999, pages 9881 - 9882, XP002210927
N. BATE ET AL.: "Thy mycarose biosynthetic genes of Streptomyces fradiae, producer of tylosin", MICROBIOLOGY, vol. 146, 2000, pages 139 - 146, XP002284343
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