Title:
POLYMORPHIC AND AMORPHOUS FORMS OF CORTISOL 17-ALPHA-BENZOATE AND METHODS FOR THE PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/089471
Kind Code:
A3
Abstract:
Provided herein are multiple solid forms of a defined steroid-like compound, and methods for the preparation and use thereof. In one aspect, there is provided a crystalline form of said steroid-like compound, and methods for the preparation and use thereof. In another aspect, there is provided a substantially amorphous form of said steroid-like compound, and methods for the preparation and use thereof. In yet another aspect, there are provided compositions containing compounds according to the present invention. In certain aspects, such compositions are suitable for delivery of active agents according to the present invention to a subject in need thereof. In another aspect of the invention, there are provided methods for the treatment of a variety of indications, including glaucoma, ocular hypertension, and the like. In still another aspect of the present invention, there are provided kits containing compounds according to the present invention and/or compositions containing same.
Inventors:
FENG SHAOXIN (US)
SMITH SCOTT W (US)
LAMBERT OLIVIER M G (FR)
BUTTAR SUZANNE (GB)
SMITH SCOTT W (US)
LAMBERT OLIVIER M G (FR)
BUTTAR SUZANNE (GB)
Application Number:
PCT/US2014/070147
Publication Date:
November 19, 2015
Filing Date:
December 12, 2014
Export Citation:
Assignee:
ALLERGAN INC (US)
International Classes:
A61K31/573; C07J5/00; A61P27/06
Domestic Patent References:
| WO2013071009A1 | 2013-05-16 | |||
| WO2013071010A1 | 2013-05-16 |
Foreign References:
| GB1202626A | 1970-08-19 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SOTA, KAORU ET AL: "Synthesis and antiinflammatory activity of hydrocortisone 17,21-diesters", XP002736772, retrieved from STN Database accession no. 1982:492625
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TACHI, YASUHIDE ET AL: "17.alpha.-Acyloxy-21-hydroxypregnene(or diene)-3,20-diones", XP002736773, retrieved from STN Database accession no. 1980:472097
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KAMANO, NORIAKI ET AL: "Steroid 17-esters", XP002736774, retrieved from STN Database accession no. 1978:121548
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TACHI, YASUHIDE ET AL: "17.alpha.-Acyloxy-21-hydroxypregnene(or diene)-3,20-diones", XP002736773, retrieved from STN Database accession no. 1980:472097
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KAMANO, NORIAKI ET AL: "Steroid 17-esters", XP002736774, retrieved from STN Database accession no. 1978:121548
Attorney, Agent or Firm:
BASS, Jonathan Y. et al. (Irvine, California, US)
Download PDF: