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Title:
POLYPEPTIDE COMPRISING IL-1R1 BINDING DOMAIN AND CARRYING MOIETY
Document Type and Number:
WIPO Patent Application WO/2019/230866
Kind Code:
A1
Abstract:
The present invention relates to a polypeptide comprising an antigen binding domain and a carrying moiety having an inhibiting domain that inhibits the antigen binding activity of the antigen binding domain, and having a longer half-life than that of the antigen binding domain existing alone, methods for producing and screening for the polypeptide, a pharmaceutical composition comprising the polypeptide, methods for producing and screening for an antigen binding domain whose antigen binding activity is inhibited by associating with particular VL, VH or VHH, and a fusion polypeptide library including an antigen binding domain whose antigen binding activity is inhibited by associating with particular VL, VH or VHH.

Inventors:
HOSHINO MAIKO (SG)
IGAWA TOMOYUKI (SG)
HIRONIWA NAOKA (JP)
Application Number:
PCT/JP2019/021462
Publication Date:
December 05, 2019
Filing Date:
May 30, 2019
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N15/13
Domestic Patent References:
WO2010081173A22010-07-15
WO2007063308A22007-06-07
WO2008149149A22008-12-11
WO2012025525A12012-03-01
WO2013128194A12013-09-06
WO2009021754A22009-02-19
WO2019107380A12019-06-06
Foreign References:
CA3041279A12018-05-31
Other References:
See also references of EP 3802831A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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