Title:
POLYPEPTIDE FRAGMENT C AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/167000
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biomedicine, and specifically relates to a polypeptide fragment C and an application thereof, the polypeptide fragment C having the amino acid sequence shown in SEQ ID NO. 1, wherein the amino acid Xaa at position 9 is Tyr, Val, Gly, Ser or Gln, the amino acid Xaa at position 20 is Ser, Gln, Glu or Tyr, the amino acid Xaa at position 30 is Asn, Thr, Ser, Pro or Leu, and the amino acid Xaa at position 42 is Gly, Arg or Met, or is not present. MP-C significantly improves the colon pathological morphology of an IBD mouse model, reduces disease activity indices and colon histopathological scores, and has the ability to interfere with the occurrence of inflammatory bowel disease in mice.
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Inventors:
ZHANG CAIHUA (CN)
CHANG YING (CN)
CHANG YING (CN)
Application Number:
PCT/CN2022/080881
Publication Date:
August 11, 2022
Filing Date:
March 15, 2022
Export Citation:
Assignee:
SHANGHAI LONGXIN BIOMEDICAL TECH CO LTD (CN)
International Classes:
C07K14/335; A23L33/18; A61K38/16; A61P1/00
Foreign References:
| CN112812158A | 2021-05-18 | |||
| CN103044532A | 2013-04-17 | |||
| CN101759781A | 2010-06-30 | |||
| CN102375062A | 2012-03-14 |
Other References:
QU XIAO;YIN MINGMING;SHEN TONGYI;YAN XUEBING;QIN HUANLONG: "Cytotoxicity of Micro Integral Membrane Protein against Intestinal Epithelial Caco-2 Cells", CHINESE JOURNAL OF MICROECOLOGY, vol. 30, no. 7, 15 July 2018 (2018-07-15), pages 745 - 749, XP055956781, ISSN: 1005-376x, DOI: 10.13381/j.cnki.cjm.201807001
YIN MINGMING;SHEN TONGYI;QIN HUANLONG: "MIMP in Different Ways Improves the Intestinal Barrier Dysfunction and Inflammatory Cytokine Levels of Mice with Inflammatory Bowel Disease", CHINESE JOURNAL OF MICROECOLOGY, vol. 28, no. 9, 15 September 2016 (2016-09-15), pages 993 - 998, XP055956786, ISSN: 1005-376x, DOI: 10.13381/j.cnki.cjm.201609001
YIN MINGMING;SHEN TONGYI;QIN HUANLONG: "MIMP in Different Ways Improves the Intestinal Barrier Dysfunction and Inflammatory Cytokine Levels of Mice with Inflammatory Bowel Disease", CHINESE JOURNAL OF MICROECOLOGY, vol. 28, no. 9, 15 September 2016 (2016-09-15), pages 993 - 998, XP055956786, ISSN: 1005-376x, DOI: 10.13381/j.cnki.cjm.201609001
Attorney, Agent or Firm:
CHANGZHOU BAIYETENGFEI PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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