Title:
POLYPEPTIDE HAVING MMP2-INHIBITORY EFFECT
Document Type and Number:
WIPO Patent Application WO/2021/090959
Kind Code:
A1
Abstract:
The present invention provides a substituted polypeptide having the effect of inhibiting MMP2 and represented by formula [I'], or a pharmaceutically acceptable salt thereof.
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Inventors:
HAYASHI MASATO (JP)
TAKEUCHI TOMOKI (JP)
NOMURA YUSAKU (JP)
TAMITA TOMOKO (JP)
SHIMONO RIE (JP)
TAKEUCHI TOMOKI (JP)
NOMURA YUSAKU (JP)
TAMITA TOMOKO (JP)
SHIMONO RIE (JP)
Application Number:
PCT/JP2020/042350
Publication Date:
May 14, 2021
Filing Date:
November 06, 2020
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K7/06; A61K38/07; A61K38/08; A61P35/00; A61P43/00; C12N9/99
Foreign References:
| US20110171133A1 | 2011-07-14 | |||
| JP2018197251A | 2018-12-13 | |||
| JP2014526459A | 2014-10-06 | |||
| JP2009235071A | 2009-10-15 |
Other References:
SANTOS, M. AMELIA ET AL.: "Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2006, pages 7539 - 7550, XP025132816, DOI: 10.1016/j.bmc. 2006.07.01 1
HIGASHI, SHOUICHI ET AL.: "Identification of a Region of beta-Amyloid Precursor Protein Essential for Its Gelatinase A Inhibitory Activity", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 16, 2003, pages 14020 - 14028, XP008136969, DOI: 10.1074/jbc.M212264200
H. J. RAW. C. PARKS, MATRIX BIOL., vol. 26, no. 8, 2007, pages 587 - 596
A. H. DRUMMOND ET AL., ANN N Y ACAD SCI., vol. 878, 1999, pages 228 - 235
A. D. BAXTER ET AL., BIOORG MED CHEM LETT., vol. 11, 2001, pages 1465 - 1468
T. ITOHETAL., CANCER RES., vol. 58, 1998, pages 1048 - 1051
R. ROY ET AL., J CLIN ONCOL., vol. 27, 2009, pages 5287 - 5297
T. TURPEENNIEMI-HUJANEN, BIOCHIMIE., vol. 87, 2005, pages 287 - 297
S. CHENG ET AL., FASEB J., vol. 20, 2006, pages 1898 - 1900
K. PAWLAK ET AL., CLIN BIOCHEM., vol. 44, 2011, pages 838 - 843
H. R. CHANG ET AL., CLIN CHIM ACTA., vol. 366, 2006, pages 243 - 248
X. DU ET AL., LAB INVEST., vol. 92, 2012, pages 1149 - 1160
M. K. TVEITARAS ET AL., PLOS ONE., vol. 10, 2015, pages e0143390
M. SELMAN ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL., vol. 279, 2000, pages L562 - L574
M. SUGA ET AL., AM J RESPIR CRIT CARE MED., vol. 162, 2000, pages 1949 - 1956
M. CORBEL ET AL., J PATHOL., vol. 193, 2001, pages 538 - 545
J. MICHAEL ET AL., AM J RESPIR CELL MOL BIOL., vol. 41, 2009, pages 731 - 741
A. TOKITO ET AL., INT J MOL SCI., vol. 17, 2016, pages E1178
D. E. LEVY ET AL., J MED CHEM., vol. 41, 1998, pages 640 - 649
S. HIGASHI ET AL., J BIOL CHEM., vol. 278, 2003, pages 14020 - 14028
See also references of EP 4056581A4
HIGASHI, SHOUICHI ET AL.: "Identification of a Region of beta-Amyloid Precursor Protein Essential for Its Gelatinase A Inhibitory Activity", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 16, 2003, pages 14020 - 14028, XP008136969, DOI: 10.1074/jbc.M212264200
H. J. RAW. C. PARKS, MATRIX BIOL., vol. 26, no. 8, 2007, pages 587 - 596
A. H. DRUMMOND ET AL., ANN N Y ACAD SCI., vol. 878, 1999, pages 228 - 235
A. D. BAXTER ET AL., BIOORG MED CHEM LETT., vol. 11, 2001, pages 1465 - 1468
T. ITOHETAL., CANCER RES., vol. 58, 1998, pages 1048 - 1051
R. ROY ET AL., J CLIN ONCOL., vol. 27, 2009, pages 5287 - 5297
T. TURPEENNIEMI-HUJANEN, BIOCHIMIE., vol. 87, 2005, pages 287 - 297
S. CHENG ET AL., FASEB J., vol. 20, 2006, pages 1898 - 1900
K. PAWLAK ET AL., CLIN BIOCHEM., vol. 44, 2011, pages 838 - 843
H. R. CHANG ET AL., CLIN CHIM ACTA., vol. 366, 2006, pages 243 - 248
X. DU ET AL., LAB INVEST., vol. 92, 2012, pages 1149 - 1160
M. K. TVEITARAS ET AL., PLOS ONE., vol. 10, 2015, pages e0143390
M. SELMAN ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL., vol. 279, 2000, pages L562 - L574
M. SUGA ET AL., AM J RESPIR CRIT CARE MED., vol. 162, 2000, pages 1949 - 1956
M. CORBEL ET AL., J PATHOL., vol. 193, 2001, pages 538 - 545
J. MICHAEL ET AL., AM J RESPIR CELL MOL BIOL., vol. 41, 2009, pages 731 - 741
A. TOKITO ET AL., INT J MOL SCI., vol. 17, 2016, pages E1178
D. E. LEVY ET AL., J MED CHEM., vol. 41, 1998, pages 640 - 649
S. HIGASHI ET AL., J BIOL CHEM., vol. 278, 2003, pages 14020 - 14028
See also references of EP 4056581A4
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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