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Title:
PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME ISOLATES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2006034319
Kind Code:
A3
Abstract:
A method of predicting the virulence of a new or uncharacterized PRRS virus isolate is provided wherein the isolate is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus isolate of known virulence, as a measure of the virulence of the new or uncharacterized isolate. Additionally, a method of selecting an isolate for inclusion in an immunogenic composition based on the predicted virulence is also provided, together with compositions incorporating attenuated forms of viruses predicted to be virulent.

Inventors:
ROOF MICHAEL (US)
VAUGHN ERIC (US)
JOHNSON WESLEY (US)
Application Number:
PCT/US2005/033760
Publication Date:
July 27, 2006
Filing Date:
September 21, 2005
Export Citation:
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Assignee:
BOEHRINGER INGELHEIM VETMED (US)
ROOF MICHAEL (US)
VAUGHN ERIC (US)
JOHNSON WESLEY (US)
International Classes:
C12Q1/70; C12N7/00; C12N7/02; C12N7/04; C12N7/08
Foreign References:
Other References:
OPRIESSNIG T. ET AL.: "Comparison of Molecular and Biological Characteristics of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Vaccine (Ingelvac PRRS MLV), the Parent Strain of the Vaccine (ATCC VR2332), ATCC VR2385, and Two Recent Field.......", JOURNAL OF VIROLOGY, vol. 76, no. 23, December 2002 (2002-12-01), pages 11837 - 11844, XP002997173
JOHNSON W. ET AL.: "Pathogenic and humoral immune responses to porcine reproductive and respiratory syndrome virus (PRRSV) are related to viral load in acute infection", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 102, no. 3, 8 December 2004 (2004-12-08), pages 233 - 247, XP004613292
MENG X.J.: "Heterogeneity of porcine reproductive and respiratory syndrome virus implications for current vaccine efficacy and future vaccine development", VETERINARY MICROBIOLOGY, vol. 74, no. 4, 12 June 2000 (2000-06-12), pages 309 - 329, XP002997174
See also references of EP 1794329A4
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