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Patent Searching and Data


Title:
PORPHYRIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2004076461
Kind Code:
A9
Abstract:
The present invention relates to a compound of formula (I) wherein one or two of A, B, C and D are each independently selected from S, O, Se and Te, and the remainder are N; a, b, c and d are each independently substituted or unsubstituted 5-membered heterocyclic groups having the members necessary to complete a porphyrin, chlorin, bacteriochlorin or isobacteriochlorin nucleus in which one or two of the nitrogens are replaced by S, O, Se or Te; M is H or a metal; R1, R2, R3 and R4 are each independently selected from: H; alkyl; cycloalkyl; halogen; aryl or heteroaryl, each of which may be optionally substituted by one or more substituents selected from OH, CN, CF3, alkyl, alkoxy, haloalkyl, halogen, an isothiocyanate group, a haloacetamide, maleimide, NH2, NO2, CONH2, COOH, COO-alkyl, -OZ, -COOZ, a polyethylene glycol group, an alkyl sulfonate group, an alkyl-COOH group, a substituted or unsubstituted benzyl group, a sugar derivative, -C=C-(CH2)pCO2R10, where R10 is H or alkyl, and O(CH2)rCOR11, where R11 is OH, O-alkyl or -N-succinimide, and p and r are each independently an integer from 1 to 10; formula (II) wherein W is an aryl, alkyl or heteroaryl group, each of which may be optionally substituted by one or more substituents listed above where Z is a silicon-containing protecting groups; and wherein when a, b, c and d have the members necessary to complete a porphyrin nucleus in which one or two of the nitrogens are replaced by S, O, Se or Te, (c) R1, R2 and R3 are identical, and R4 <>R1, R2, R3; or (d) R1=R3; R2=R4, where R1, R3 <>R2, R4; or (d) R2=R3; R1 <>R4; and R1, R 4 <>R2, R3.

Inventors:
YAHIOGLU GOKHAN (GB)
MASON PETER (GB)
Application Number:
PCT/GB2004/000773
Publication Date:
November 10, 2005
Filing Date:
February 26, 2004
Export Citation:
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Assignee:
PHOTOBIOTICS LTD (GB)
YAHIOGLU GOKHAN (GB)
MASON PETER (GB)
International Classes:
C07D513/22; (IPC1-7): C07D495/22
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