Title:
POTASSIUM CHANNEL OPENERS
Document Type and Number:
WIPO Patent Application WO2002062762
Kind Code:
A3
Abstract:
Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Inventors:
ALTENBACH ROBERT J
BAI HAO
BRIONI JORGE D
CARROLL WILLIAM A
GOPALAKRISHNAN MURALI
GREGG ROBERT J
HOLLADAY MARK W
HUANG PEGGY P
KINCAID JOHN F
KORT MICHAEL E
KYM PHILIP R
LYNCH JOHN K
PEREZ-MEDRANO ARTURO
ZHANG HENRY Q
BAI HAO
BRIONI JORGE D
CARROLL WILLIAM A
GOPALAKRISHNAN MURALI
GREGG ROBERT J
HOLLADAY MARK W
HUANG PEGGY P
KINCAID JOHN F
KORT MICHAEL E
KYM PHILIP R
LYNCH JOHN K
PEREZ-MEDRANO ARTURO
ZHANG HENRY Q
Application Number:
PCT/US2002/005252
Publication Date:
July 31, 2003
Filing Date:
January 17, 2002
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
A61K31/17; A61K31/275; A61K31/4164; A61K31/4406; A61K31/455; A61K31/47; A61K31/505; A61P1/00; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/00; A61P13/08; A61P13/10; A61P15/00; A61P15/06; A61P15/10; A61P17/00; A61P17/14; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/18; A61P25/28; A61P43/00; C07C233/36; C07C233/78; C07C233/83; C07C255/61; C07C271/22; C07C275/28; C07C275/30; C07C279/28; C07C279/36; C07C335/16; C07C335/18; C07C335/20; C07D209/08; C07D209/30; C07D213/40; C07D213/74; C07D213/75; C07D213/82; C07D215/38; C07D233/42; C07D233/84; C07D235/06; C07D239/42; C07D333/20; C07D401/04; C07D401/12; C07D405/12; C07D409/12; (IPC1-7): C07D213/75; A61K31/4406; A61K31/275; A61K31/17; A61P11/00; A61P15/00; A61P25/00; C07C335/16; C07C335/18; C07D233/84; C07C275/28; C07C279/28; C07D239/42; C07D215/38; A61P1/00; A61P9/00; A61P17/00; A61P13/00
Domestic Patent References:
| WO2001009096A2 | 2001-02-08 |
Foreign References:
| FR1363904A | 1964-06-19 | |||
| FR2000369A1 | 1969-09-05 | |||
| FR2005935A1 | 1969-12-19 | |||
| DE1916174A1 | 1969-10-23 | |||
| EP0044417A2 | 1982-01-27 | |||
| EP0503627A1 | 1992-09-16 | |||
| EP0501797A1 | 1992-09-02 | |||
| EP0381504A2 | 1990-08-08 | |||
| FR2023940A1 | 1970-08-21 | |||
| FR2340927A1 | 1977-09-09 |
Other References:
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DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BOEHME, H. ET AL: "N-(.alpha.-Haloalkyl)carboxamides. 20. Imidomethyl thiocyanates and isothiocyanates", XP002151941, retrieved from STN Database accession no. 82:3924
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ALY, N. F., MRS. ET AL: "Acid azides: part IX - synthesis and reactions of phthalimidoacetic acid azide and its derivatives", XP002151939, retrieved from STN Database accession no. 101:110675
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ESSAWY, SAMY A. ET AL: "Synthesis and reactions of phthalimido aliphatic acid azides", XP002151936, retrieved from STN Database accession no. 116:173943
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; EYADA, H. A.: "Synthesis of some 4,5,6,7-tetrachlorophthalimido containing benzoxazole, benzimidazole, benzoxazine, and carbamate moieties", XP002151933, retrieved from STN Database accession no. 124:289398
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOHAMED, Y. A.: "Synthesis and reactions of some new 5,6-dichlorophthalimidoacetic acid derivatives", XP002151934, retrieved from STN Database accession no. 118:38720
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MURAKAMI, MAKOTO: "Process for preparing isoindolone derivatives", XP002238887, retrieved from STN Database accession no. 136:5899
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; LUK'YANOV, O. A. ET AL: "N,N'-Diacylated imidazolidines and hexahydropyrimidines", XP002238888, retrieved from STN Database accession no. 122:133113
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MORIGAKI, MASAKAZU ET AL: "Silver halide color photographic material containing nitrogen heterocycles", XP002238889, retrieved from STN Database accession no. 115:60742
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VIDA, JULIUS A. ET AL: "Anticonvulsants. 2. Acyloxymethyl and halomethyl derivatives of barbituric acid and diphenylhydantoin", XP002238890, retrieved from STN Database accession no. 74:99983
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PORRET, DANIEL ET AL: "Heterocyclic binuclear N,N'-diglycidyl compounds", XP002238891, retrieved from STN Database accession no. 76:141702
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KNOTZ, FL.: "Manufacture of antiviral and antimicrobial substances. 5. 1-Isatinylmethyl derivatives of NH-acidic compounds", XP002238892, retrieved from STN Database accession no. 79:92152
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PORRET, DANIEL: "Chemistry of epoxy resins. XIV. Synthesis of new cyclic N-glycidylamides", XP002238893, retrieved from STN Database accession no. 67:108599
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PORRET, DANIEL: "1,1'-methylenebis[3-glycidylhydantoin]", XP002238897, retrieved from STN Database accession no. 70:87806 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PORRET, DANIEL: "1,.omega.-Bis[N-glycidyl-5,5-dimethyl-3-hydantoinyl]alkanes", XP002238898, retrieved from STN Database accession no. 71:49940 CA
FENG L ET AL: "Selective fluorescence derivatization and capillary electrophoretic separation of amidated amino acids", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 832, no. 1-2, 5 January 1999 (1999-01-05), pages 211 - 224, XP004156180, ISSN: 0021-9673
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AMMAR, Y. V. ET AL: "Some reactions with the unusual amino acid DL-C-phenylglycine", XP002151935, retrieved from STN Database accession no. 117:131520
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VINOGRADOVA, T. K. ET AL: "Intramolecular cyclization and annulation in dehydrochlorination of products of addition of amines to carboxylic acid N-(1-isothiocyanato-2,2-dichloroethyl)amides", XP002151937, retrieved from STN Database accession no. 114:61984
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BOYER, JOSEPH H. ET AL: "Alkylation of nitrocyanamide. A new synthesis of isocyanates", XP002151938, retrieved from STN Database accession no. 110:94646
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TIWARI, S. S. ET AL: "Synthesis of possible antiparkinsonian compounds. VIII. Synthesis of N1-(nicotinamidomethyl)-N3-arylureas and N1-[2-(o- methylbenzimidazolyl)salicylamidomethyl]-N3-arylureas", XP002151940, retrieved from STN Database accession no. 84:17225
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DRACH, B. S. ET AL: "Reaction of N-chloromethyl acid amides with silver isocyanate and potassium isothiocyanate", XP002151942, retrieved from STN Database accession no. 78:15735
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOFFATT, J. G. ET AL: "Carbodiimide-sulfoxide reactions. XI. Reactions of carboxylic acids, hydroxamic acids, and amides", XP002151943, retrieved from STN Database accession no. 76:3528
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DRACH, B. S. ET AL: "N-(1,2,2,2-Tetrachloroethyl) amides", XP002151944, retrieved from STN Database accession no. 75:63069
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FEST, CHRISTA ET AL: "Pesticidal fluoroacetylaminotrichloromethylmethylthiocarbamic acid esters and ureas", XP002151945, retrieved from STN Database accession no. 73:130653
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BOEHME, H. ET AL: "N-(.alpha.-Haloalkyl)carboxamides. 20. Imidomethyl thiocyanates and isothiocyanates", XP002151941, retrieved from STN Database accession no. 82:3924
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ALY, N. F., MRS. ET AL: "Acid azides: part IX - synthesis and reactions of phthalimidoacetic acid azide and its derivatives", XP002151939, retrieved from STN Database accession no. 101:110675
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ESSAWY, SAMY A. ET AL: "Synthesis and reactions of phthalimido aliphatic acid azides", XP002151936, retrieved from STN Database accession no. 116:173943
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; EYADA, H. A.: "Synthesis of some 4,5,6,7-tetrachlorophthalimido containing benzoxazole, benzimidazole, benzoxazine, and carbamate moieties", XP002151933, retrieved from STN Database accession no. 124:289398
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOHAMED, Y. A.: "Synthesis and reactions of some new 5,6-dichlorophthalimidoacetic acid derivatives", XP002151934, retrieved from STN Database accession no. 118:38720
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MURAKAMI, MAKOTO: "Process for preparing isoindolone derivatives", XP002238887, retrieved from STN Database accession no. 136:5899
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; LUK'YANOV, O. A. ET AL: "N,N'-Diacylated imidazolidines and hexahydropyrimidines", XP002238888, retrieved from STN Database accession no. 122:133113
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MORIGAKI, MASAKAZU ET AL: "Silver halide color photographic material containing nitrogen heterocycles", XP002238889, retrieved from STN Database accession no. 115:60742
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VIDA, JULIUS A. ET AL: "Anticonvulsants. 2. Acyloxymethyl and halomethyl derivatives of barbituric acid and diphenylhydantoin", XP002238890, retrieved from STN Database accession no. 74:99983
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PORRET, DANIEL ET AL: "Heterocyclic binuclear N,N'-diglycidyl compounds", XP002238891, retrieved from STN Database accession no. 76:141702
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KNOTZ, FL.: "Manufacture of antiviral and antimicrobial substances. 5. 1-Isatinylmethyl derivatives of NH-acidic compounds", XP002238892, retrieved from STN Database accession no. 79:92152
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PORRET, DANIEL: "Chemistry of epoxy resins. XIV. Synthesis of new cyclic N-glycidylamides", XP002238893, retrieved from STN Database accession no. 67:108599
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PORRET, DANIEL: "1,1'-methylenebis[3-glycidylhydantoin]", XP002238897, retrieved from STN Database accession no. 70:87806 CA
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; PORRET, DANIEL: "1,.omega.-Bis[N-glycidyl-5,5-dimethyl-3-hydantoinyl]alkanes", XP002238898, retrieved from STN Database accession no. 71:49940 CA
FENG L ET AL: "Selective fluorescence derivatization and capillary electrophoretic separation of amidated amino acids", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER SCIENCE, NL, vol. 832, no. 1-2, 5 January 1999 (1999-01-05), pages 211 - 224, XP004156180, ISSN: 0021-9673
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AMMAR, Y. V. ET AL: "Some reactions with the unusual amino acid DL-C-phenylglycine", XP002151935, retrieved from STN Database accession no. 117:131520
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VINOGRADOVA, T. K. ET AL: "Intramolecular cyclization and annulation in dehydrochlorination of products of addition of amines to carboxylic acid N-(1-isothiocyanato-2,2-dichloroethyl)amides", XP002151937, retrieved from STN Database accession no. 114:61984
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BOYER, JOSEPH H. ET AL: "Alkylation of nitrocyanamide. A new synthesis of isocyanates", XP002151938, retrieved from STN Database accession no. 110:94646
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TIWARI, S. S. ET AL: "Synthesis of possible antiparkinsonian compounds. VIII. Synthesis of N1-(nicotinamidomethyl)-N3-arylureas and N1-[2-(o- methylbenzimidazolyl)salicylamidomethyl]-N3-arylureas", XP002151940, retrieved from STN Database accession no. 84:17225
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DRACH, B. S. ET AL: "Reaction of N-chloromethyl acid amides with silver isocyanate and potassium isothiocyanate", XP002151942, retrieved from STN Database accession no. 78:15735
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MOFFATT, J. G. ET AL: "Carbodiimide-sulfoxide reactions. XI. Reactions of carboxylic acids, hydroxamic acids, and amides", XP002151943, retrieved from STN Database accession no. 76:3528
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DRACH, B. S. ET AL: "N-(1,2,2,2-Tetrachloroethyl) amides", XP002151944, retrieved from STN Database accession no. 75:63069
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FEST, CHRISTA ET AL: "Pesticidal fluoroacetylaminotrichloromethylmethylthiocarbamic acid esters and ureas", XP002151945, retrieved from STN Database accession no. 73:130653
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