Title:
POTENT INHIBITORS OF D-AMINO ACID OXIDASE (DAAO) AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/228408
Kind Code:
A1
Abstract:
Provided herein are potent compounds of Formula (I) and uses thereof for inhibiting the activity of D-amino acid oxidase (DAAO) or treating diseases or disorders associated with DAAO, such as a central nervous system (CNS) disorder, pain, obesity, diabetes, or hyperlipidemia. Also provided in the present disclosure are methods of synthesizing the Formula (I) compounds described herein. (I)
Inventors:
TSAI GUOCHUAN EMIL (US)
WANG CHING-CHENG (CN)
CHIEN MING-HONG (CN)
HSIEH TIEN-LAN (CN)
WANG CHING-CHENG (CN)
CHIEN MING-HONG (CN)
HSIEH TIEN-LAN (CN)
Application Number:
PCT/CN2019/089044
Publication Date:
December 05, 2019
Filing Date:
May 29, 2019
Export Citation:
Assignee:
SYNEURX INT TAIWAN CORP (CN)
International Classes:
C07C69/88; C07H13/08
Domestic Patent References:
| WO2008131047A2 | 2008-10-30 |
Foreign References:
| CN105592892A | 2016-05-18 |
Other References:
HU, ZHI QING ET AL.: "Mitogenic activity of (-)epigallocatechin gallate on B-cells and investigation of its structure-function relationship", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 14, no. 8, 31 December 1992 (1992-12-31), pages 1399 - 1407, XP026042038, DOI: 10.1016/0192-0561(92)90011-9
SEKOWSKI, SZYMON ET AL.: "Interaction of a-synuclein with Rhus typhina tannin - Implication for Parkinson's disease", COLLOIDS AND SURFACES, B: BIOINTERFACES, vol. 155, 10 April 2017 (2017-04-10), pages 159 - 165, XP085047936
NISHIZAWA, MAKOTO ET AL.: "Structure of gallotannins in Paeoniae radix", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 28, no. 9, 31 December 1980 (1980-12-31), pages 2850 - 2852, XP055659458
S YLLA, TAHIRI ET AL.: "Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid (3-Peptide Aggregation", ANGEWANDTE CHEMIE, vol. 54, no. 28, 26 May 2015 (2015-05-26), pages 8217 - 8221, XP055659459
See also references of EP 3802478A4
SEKOWSKI, SZYMON ET AL.: "Interaction of a-synuclein with Rhus typhina tannin - Implication for Parkinson's disease", COLLOIDS AND SURFACES, B: BIOINTERFACES, vol. 155, 10 April 2017 (2017-04-10), pages 159 - 165, XP085047936
NISHIZAWA, MAKOTO ET AL.: "Structure of gallotannins in Paeoniae radix", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 28, no. 9, 31 December 1980 (1980-12-31), pages 2850 - 2852, XP055659458
S YLLA, TAHIRI ET AL.: "Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on Alzheimer's Amyloid (3-Peptide Aggregation", ANGEWANDTE CHEMIE, vol. 54, no. 28, 26 May 2015 (2015-05-26), pages 8217 - 8221, XP055659459
See also references of EP 3802478A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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