Title:
POWDER CONTAINING ANHYDROUS CRYSTALS OF 2-O-Α-D-GLUCOSYL-L-ASCORBIC ACID, MANUFACTURING METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/027790
Kind Code:
A1
Abstract:
Provided is a powder containing anhydrous crystals of ascorbic acid 2-glucoside, said powder being significantly less prone to caking than existing general-purpose quasi-drug-class powders containing anhydrous crystals of ascorbic acid 2-glucoside. Also provided are a method for manufacturing the aforementioned powder and a use thereof. The provided powder containing anhydrous crystals of ascorbic acid 2-glucoside contains, in terms of anhydride content, greater than 98.0% and less than 99.9% ascorbic acid 2-glucoside, by mass. Furthermore, either the crystallinity of the anhydrous crystals of ascorbic acid 2-glucoside is at least 90%, as calculated on the basis of a powder X-ray diffraction profile, or after free moisture has been removed from the provided powder in a nitrogen stream, the dynamic amount of moisture absorbed by said powder after 12 hours at a temperature of 25°C and a relative humidity of 35% is no more than 0.01% by mass.
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Inventors:
SHIBUYA TAKASHI (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
Application Number:
PCT/JP2010/064947
Publication Date:
March 10, 2011
Filing Date:
September 01, 2010
Export Citation:
Assignee:
HAYASHIBARA BIOCHEM LAB (JP)
SHIBUYA TAKASHI (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
SHIBUYA TAKASHI (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
International Classes:
C12P19/58; A23L33/15; C07H1/06; C07H17/04; C12N15/09
Foreign References:
JPH03139288A | 1991-06-13 | |||
JPH03135992A | 1991-06-10 | |||
JPH03183492A | 1991-08-09 | |||
JPH05117290A | 1993-05-14 | |||
JPH05208991A | 1993-08-20 | |||
JP2002088095A | 2002-03-27 |
Attorney, Agent or Firm:
SUMA Mitsuo (JP)
Suma Mitsuo (JP)
Suma Mitsuo (JP)
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