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Title:
POWDER CONTAINING ANHYDROUS CRYSTALS OF 2-O-Α-D-GLUCOSYL-L-ASCORBIC ACID, MANUFACTURING METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/027790
Kind Code:
A1
Abstract:
Provided is a powder containing anhydrous crystals of ascorbic acid 2-glucoside, said powder being significantly less prone to caking than existing general-purpose quasi-drug-class powders containing anhydrous crystals of ascorbic acid 2-glucoside. Also provided are a method for manufacturing the aforementioned powder and a use thereof. The provided powder containing anhydrous crystals of ascorbic acid 2-glucoside contains, in terms of anhydride content, greater than 98.0% and less than 99.9% ascorbic acid 2-glucoside, by mass. Furthermore, either the crystallinity of the anhydrous crystals of ascorbic acid 2-glucoside is at least 90%, as calculated on the basis of a powder X-ray diffraction profile, or after free moisture has been removed from the provided powder in a nitrogen stream, the dynamic amount of moisture absorbed by said powder after 12 hours at a temperature of 25°C and a relative humidity of 35% is no more than 0.01% by mass.

Inventors:
SHIBUYA TAKASHI (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
Application Number:
PCT/JP2010/064947
Publication Date:
March 10, 2011
Filing Date:
September 01, 2010
Export Citation:
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Assignee:
HAYASHIBARA BIOCHEM LAB (JP)
SHIBUYA TAKASHI (JP)
IZAWA SEISUKE (JP)
NISHIMOTO TOMOYUKI (JP)
FUKUDA SHIGEHARU (JP)
MIYAKE TOSHIO (JP)
International Classes:
C12P19/58; A23L33/15; C07H1/06; C07H17/04; C12N15/09
Foreign References:
JPH03139288A1991-06-13
JPH03135992A1991-06-10
JPH03183492A1991-08-09
JPH05117290A1993-05-14
JPH05208991A1993-08-20
JP2002088095A2002-03-27
Attorney, Agent or Firm:
SUMA Mitsuo (JP)
Suma Mitsuo (JP)
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