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Title:
A PRECESS FOR PREPARATION OF TIMOSAPONIN B II
Document Type and Number:
WIPO Patent Application WO/2005/105824
Kind Code:
A1
Abstract:
A precess for preparation of timosaponin B II, which uses Chinese traditional drug Anemarrhena Rhizome or newly collected rhizoma or fibrous root of Anemarrhena Asphodeloides Bge. as raw material, and comprises isolation of tiBosaponin B II by one or more steps selected from solvent extraction, resin adsorption, polyamide chromatography, inversed phase column chromatography, column chromatography on Sephadex LH-20 and so on in combination with conventional drying method such as vacuum drying, freeze drying, spray drying and so on. Timosaponin B II obtained by the present process is of over 90% purity, and the process is simple and applicable and suitable for industrial production.

Inventors:
MA BAIPING (CN)
CHEN HAO (CN)
XIONG CHENGQI (CN)
KANG LIPING (CN)
ZHANG JIE (CN)
Application Number:
PCT/CN2005/000554
Publication Date:
November 10, 2005
Filing Date:
April 21, 2005
Export Citation:
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Assignee:
INST RADIATION MED AMMS PLA (CN)
MA BAIPING (CN)
CHEN HAO (CN)
XIONG CHENGQI (CN)
KANG LIPING (CN)
ZHANG JIE (CN)
International Classes:
C07J53/00; C07J71/00; (IPC1-7): C07J71/00
Foreign References:
JP2000204043A2000-07-25
JPH0454194A1992-02-21
Other References:
BAIPING MA. ET AL: "Studies on the furostanol saponins from Anamarrhena asphodeloides Bunge.", vol. 31, no. 4, 1996, pages 271 - 277, XP008054989
ZHANG J. ET AL: "Effect of six steroidal saponins isolated from anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood.", CLINICA CHIMICA ACTA., vol. 289, no. 1-2, 1999, pages 79 - 88, XP002409220
NOBORU NAKASHIMA ET AL: "Isolation of pseudoprototimosaponin AIII from rhizomes of Anemarrhena asphodeloides and its hypoglycemic activity in streptozotocin-induced diabetic mice.", J NAT PROD., vol. 56, no. 3, March 1993 (1993-03-01), pages 345 - 350, XP003009420
See also references of EP 1752464A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (Vantone New World Plaza Fuchengmenwai Street, Beijing 7, CN)
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