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Title:
PREPARATION, IMPURITY REMOVAL AND PURIFICATION METHODS FOR GLYCYRRHIZIC ACID MONOVALENT SALT
Document Type and Number:
WIPO Patent Application WO/2021/134408
Kind Code:
A1
Abstract:
The present invention relates to preparation, impurity removal and purification methods for glycyrrhizic acid monovalent salt. The preparation method for glycyrrhizic acid monovalent salt comprises mixing a glycyrrhizinate mixture and a preparation liquid in a certain proportion, achieving a conversion reaction by means of certain steps, and obtaining glycyrrhizic acid monovalent salt having a content of about 50%, the yield of glycyrrhizic acid monovalent salt being above 83%. Furthermore, the glycyrrhizic acid monovalent salt is washed by using a washing liquid so as to remove impurities from and purify glycyrrhizinate. The described preparation method for glycyrrhizic acid monovalent salt improves the yield of glycyrrhizic acid monovalent salt, and operation is simple and easy to implement for industrialization; the impurity removal method for glycyrrhizinate can effectively reduce the content of (18β, 20β)-24-hydroxy-glycyrrhizic acid and 18α-glycyrrhizic acid (or 18β, 20α -glycyrrhizic acid) under the premise of guaranteeing a high yield of glycyrrhizinate; and the purification method for glycyrrhizinate can obtain glycyrrhizinate quickly with low energy consumption and a high yield.

Inventors:
XU JING (CN)
TAN DONGMING (CN)
TAN HAILIANG (CN)
LOU MINAN (CN)
LIU WEI (CN)
LI SONGWU (CN)
Application Number:
PCT/CN2019/130347
Publication Date:
July 08, 2021
Filing Date:
December 31, 2019
Export Citation:
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Assignee:
CHINA MEHECO CO LTD (CN)
BEIJING DIACRID MEDICAL TECH CO LTD (CN)
International Classes:
C07J63/00; C07H1/06; C07H15/256
Foreign References:
CN111018942A2020-04-17
CN111057124A2020-04-24
CN111018941A2020-04-17
CN104725458A2015-06-24
CN101260137A2008-09-10
CN101654471A2010-02-24
JPS57144297A1982-09-06
Other References:
LI, XUEYU: "Study on extraction solvent and determination of licorice chemical components", GLYCYRRHIZA (GLYCYRRHIZA L.) CLASSIFICATION SYSTEM AND EXPERIMENTAL BIOLOGY RESEARCH, 31 January 2015 (2015-01-31), CN, pages 310 - 321, XP009529203, ISBN: 978-7-309-10982-5
Attorney, Agent or Firm:
GENUINEWAYS INC. (CN)
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