Title:
PREPARATION METHOD FOR 2,4,5-TRIFLUOROPHENYLACETIC ACID
Document Type and Number:
WIPO Patent Application WO/2022/099439
Kind Code:
A1
Abstract:
A preparation method for 2,4,5-trifluorophenylacetic acid, comprising: step one, reacting raw materials, a quaternary ammonium salt catalyst, sulfolane and potassium fluoride to obtain a first intermediate; step two, subjecting the first intermediate to a hydrogenation catalytic reaction to obtain a second intermediate; step three, reacting the second intermediate with a fluorinating reagent to form a salt, quenching, and then performing a diazotization reaction with an aqueous solution of sodium nitrite to obtain a diazonium salt; step four, cracking the diazonium salt at a high temperature to obtain 2,4,5-trifluorotoluene; and steps five to seven, successively subjecting the 2,4,5-trifluorotoluene to halogenation, cyanation and hydrolysis reactions so as to obtain 2,4,5-trifluorophenylacetic acid. The raw materials of the method are easy to obtain and costs are relatively low; in addition, the yield of each step is relatively high, which is beneficial to the large-scale production of 2,4,5-trifluorophenylacetic acid.
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Inventors:
ZHANG LINGXIAO (CN)
CAI GANGHUA (CN)
CAI GANGHUA (CN)
Application Number:
PCT/CN2020/127713
Publication Date:
May 19, 2022
Filing Date:
November 10, 2020
Export Citation:
Assignee:
HANGZHOU ABSOBIOTEC CO LTD (CN)
International Classes:
C07C17/00; C07C51/08; C07C25/13; C07C57/58
Domestic Patent References:
| WO2010058421A2 | 2010-05-27 |
Foreign References:
| CN112851493A | 2021-05-28 | |||
| CN108586257A | 2018-09-28 | |||
| CN103012111A | 2013-04-03 | |||
| CN104610066A | 2015-05-13 | |||
| CN1749232A | 2006-03-22 | |||
| CN101659611A | 2010-03-03 | |||
| CN109400459A | 2019-03-01 | |||
| CN110128258A | 2019-08-16 |
Attorney, Agent or Firm:
BEIJING WEIZHENG PATENT AGENCY CO., LTD. (CN)
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