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Title:
PREPARATION METHOD FOR ANSAMYCIN GLYCOSIDE USING GLYCOSYLTRANSFERASE
Document Type and Number:
WIPO Patent Application WO/2013/058582
Kind Code:
A3
Abstract:
The present invention relates to a preparation method for an ansamycin glycoside or a non-benzoquinone geldanamycin glycoside having an ansamycin backbone using a glycosyltransferase, a non-benzoquinone geldanamycin glycoside, and a pharmaceutical composition for preventing or treating cancer containing the same as an active ingredient. By introducing a glycosyl group into ansamycin or a non-benzoquinone geldanamycin compound having an ansamycin backbone, a solubility is increased, bioavailability can be enhanced and the activity of an ansamycin-based compound is maintained, and by introducing a glycosyl group into ansamycin or a non-benzoquinone geldanamycin compound having an ansamycin backbone, and thus the present invention can be useful as an antibiotic, a fungicide, an antiviral agent, an immunosuppressive, a drug for degenerative neurological diseases, an anti-inflammatory or anticancer drug.

Inventors:
KIM JOONG SU (KR)
HONG YOUNG-SOO (KR)
WOO MI HEE (KR)
CHUN HYO KON (KR)
WU CHENGZHU (KR)
Application Number:
PCT/KR2012/008560
Publication Date:
July 04, 2013
Filing Date:
October 18, 2012
Export Citation:
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Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
International Classes:
C12P19/18; C07D225/06; C12P17/10; C12P19/26
Foreign References:
EP2292271A22011-03-09
Other References:
WU, CHENG-ZHU: "Heat shock protein 90 inhibitors geldanamycin analogs from genetically engineered Streptomyces hygroscopicus", PH. D. THESIS, September 2011 (2011-09-01)
ZHAO, P. ET AL.: "Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins", CHEMISTRY & BIOLOGY, vol. 15, 2008, pages 863 - 874, XP025533992, DOI: doi:10.1016/j.chembiol.2008.06.007
WU, CHENG-ZHU ET AL.: "New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus", THE JOURNAL OF ANTIBIOTICS, vol. 64, March 2011 (2011-03-01), pages 461 - 463
Attorney, Agent or Firm:
LEE, Won Hee (642-16 Yoksam-dongKangnam-ku, Seoul 135-080, KR)
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Claims: