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Patent Searching and Data


Title:
PREPARATION METHOD FOR AZACITIDINE INJECTION
Document Type and Number:
WIPO Patent Application WO/2017/162103
Kind Code:
A1
Abstract:
Disclosed is a preparation method for an azacitidine injection, wherein each azacitidine injection comprises 100 mg of azacitidine and 100 mg of mannitol. The preparation method comprises the steps of measuring 80% water for injection, and controlling the temperature at 2-6°C; adding mannitol, stirring until completely dissolved, and controlling the temperature at 2-6°C; adding azacitidine, stirring until completely dissolved, and controlling the temperature at 2-6°C; sub-packaging into 23 ml/bottle after filtration; freeze-drying according to a preset temperature; and tamponing, capping and packaging after nitrogen filling. The preparation method has the advantages of a simple process, low energy consumption, high production efficiency and stable product quality.

Inventors:
SHI XIANGJIE (CN)
LIU JIENING (CN)
WANG XINSHI (CN)
HU LIBIN (CN)
CHEN HAO (CN)
WANG ZHIYUN (CN)
Application Number:
PCT/CN2017/077026
Publication Date:
September 28, 2017
Filing Date:
March 17, 2017
Export Citation:
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Assignee:
ZHEJIANG HUAHAI PHARM CO LTD (CN)
International Classes:
A61K31/706; A61K9/19; A61P7/00; A61P7/06; A61P35/02; F26B5/06
Foreign References:
CN103338753A2013-10-02
CN101632643A2010-01-27
US20110042247A12011-02-24
CN105769775A2016-07-20
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
北京柏杉松知识产权代理事务所(普通合伙) (CN)
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