Title:
PREPARATION METHOD FOR CARBOXYLATE ESTER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/134297
Kind Code:
A1
Abstract:
The present invention relates to a preparation method for a carboxylate ester compound, comprising: under the catalysis of a nitrite ester, reacting carboxylic acid and methanol in air, so as to obtain an ester compound. The preparation method of the present invention has the advantages of abundant raw material sources, cheap and easily available catalysts, mild reaction conditions, simple operations, and the like, and high-yield modification of a series of fatty carboxylic acids can be achieved. In particular, it should be noted that conventional esterification methods are generally not suitable for the esterification of drug molecules. Using the present method, a series of known drug molecules can be modified, thereby providing a shortcut for the discovery of new drug molecules.
Inventors:
WAN XIAOBING (CN)
ZHENG YONGGAO (CN)
TAO SUYAN (CN)
LI XINGXING (CN)
CHENG XIONGLUE (CN)
ZHENG YONGGAO (CN)
TAO SUYAN (CN)
LI XINGXING (CN)
CHENG XIONGLUE (CN)
Application Number:
PCT/CN2021/077321
Publication Date:
June 30, 2022
Filing Date:
February 22, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07C67/08; B01J31/02; C07C69/24; C07C69/612; C07C69/616; C07C69/65; C07C69/712; C07C69/732; C07C69/734; C07C69/738; C07C201/12; C07C205/56; C07C227/16; C07C229/42; C07C231/12; C07C233/54; C07C233/63; C07C233/83; C07C269/06; C07C271/22; C07D209/28; C07D209/48; C07D209/88; C07D211/62; C07D231/56; C07D261/20; C07D313/12
Domestic Patent References:
| WO2017222692A1 | 2017-12-28 | |||
| WO2010037807A1 | 2010-04-08 |
Foreign References:
| CN101914014A | 2010-12-15 | |||
| CN107033002A | 2017-08-11 | |||
| CN108503549A | 2018-09-07 | |||
| CN109369394A | 2019-02-22 | |||
| CN101602736A | 2009-12-16 | |||
| CN108707057A | 2018-10-26 |
Other References:
YANG XU-HENG, SONG REN-JIE, LI JIN-HENG: "Metal-Free [4+2] Annulation of Arylalkynes with tert- Butyl Nitrite through C( sp 2 )H Oxidation to Assemble Benzo[ e ][1,2]oxazin-4-ones", ADVANCED SYNTHESIS AND CATALYSIS, vol. 357, no. 18, 14 December 2015 (2015-12-14), pages 3849 - 3856, XP055946649, ISSN: 1615-4150, DOI: 10.1002/adsc.201500656
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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