Title:
PREPARATION METHOD OF DROSPIRENONE
Document Type and Number:
WIPO Patent Application WO/2011/113196
Kind Code:
A1
Abstract:
Preparation method of drospirenone is disclosed, which uses 3β,5-dihydroxy-6β,7β,15β,16β-dimethylene-5β-androster-17, 20-epoxy as the starting material and comprises the following steps: oxidizing the hydroxyl group at position 3, protecting the ketone group at position 3 with ketal, constructing carboxylic inner ester by condensation and deesterifying, then sulfonylating the hydroxyl group at position 5, and constructing 3-ketone-4-alkenyl by deprotecting ketal and desulfonylation at the same time in a reaction system comprising glacial acetic acid and sodium acetate to obtain drospirenone.
Inventors:
WANG JIAZHEN (CN)
Application Number:
PCT/CN2010/071074
Publication Date:
September 22, 2011
Filing Date:
March 16, 2010
Export Citation:
Assignee:
TAIZHOU TAIFA PHARMACEUTICALS CO LTD (CN)
WANG JIAZHEN (CN)
WANG JIAZHEN (CN)
International Classes:
C07J53/00
Foreign References:
| CN101092443A | 2007-12-26 | |||
| CN101503455A | 2009-08-12 | |||
| CN1223662A | 1999-07-21 | |||
| EP0075189A1 | 1983-03-30 | |||
| CN101092443A | 2007-12-26 |
Other References:
See also references of EP 2548881A4
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
杭州天勤知识产权代理有限公司 (CN)
杭州天勤知识产权代理有限公司 (CN)
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Claims: