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Patent Searching and Data


Title:
PREPARATION METHOD OF DRUG-CONTAINING SUSTAINED RELEASE MICROPARTICLES
Document Type and Number:
WIPO Patent Application WO/2016/021835
Kind Code:
A1
Abstract:
The present invention relates to a preparation method of drug-containing sustained release microparticles, the preparation method comprising the steps of: (a) dissolving a biodegradable polymer and a drug in a halogenated alkane solvent to form a drug-containing biodegradable polymer solution; (b) homogeneously mixing the drug-containing biodegradable polymer solution in a continuous phase containing a surfactant to form a dispersed phase; (c) maintaining an emulsion comprising the continuous phase and the dispersed phase at a temperature lower than the boiling point of the halogenated alkane solvent to form microparticles in the continuous phase; (d) primarily drying the microparticles; (e) mixing the primarily dried microparticles with an aqueous alcohol solution, and then maintaining the aqueous alcohol solution at a temperature no less than the boiling point of the halogenated alkane solvent to extract and evaporate the remaining halogenated alkane solvent from the microparticles; and (f) secondarily drying the obtained microparticles to produce drug-containing microparticles. The drug-containing sustained release microparticles prepared in accordance with the preparation method of the present invention minimize the hydrolysis of the biodegradable polymer in the microparticles, while easily removing the halogenated alkane solvent in the microparticles, and are thus capable of exhibiting excellent sustained drug release.

Inventors:
SUH HEA RAN (KR)
AN TAE KUN (KR)
CHOI JU HUEN (KR)
OH SEUNG YOUN (KR)
KIM A RAM (KR)
KIM JONG MIN (KR)
AN GUG HWAN (KR)
NAM YOON JIN (KR)
JEON DAE YEON (KR)
OH YOUNG HEUN (KR)
HAN SANG MIN (KR)
BAE MIN HEE (KR)
Application Number:
PCT/KR2015/006771
Publication Date:
February 11, 2016
Filing Date:
July 01, 2015
Export Citation:
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Assignee:
BCWORLD PHARM CO LTD (KR)
International Classes:
A61K9/16; A61K31/4515; A61K47/30; A61P25/18
Domestic Patent References:
WO1999003452A11999-01-28
Foreign References:
US20120083444A12012-04-05
US20090162407A12009-06-25
US20050079224A12005-04-14
US20050276859A12005-12-15
Other References:
See also references of EP 3178471A4
Attorney, Agent or Firm:
NAM & NAM WORLD PATENT & LAW FIRM (KR)
특허법인 남앤드남 (KR)
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