Title:
PREPARATION METHOD FOR ESLICARBAZEPINE
Document Type and Number:
WIPO Patent Application WO/2021/073231
Kind Code:
A1
Abstract:
The present invention relates to the field of chemical and pharmaceutical preparation, and in particular, to a preparation method for eslicarbazepine. The method is obtained by reacting oxcarbazepine in the presence of a chiral catalyst and a hydrogen source. The reaction equation is:, wherein, the chiral catalyst can be: R1, R2, R3, R4, R5 and R6 can be hydrogen or methyl respectively; and M is Ru, Rh or Ir.
Inventors:
YU SHUAI (CN)
GAO ZHAOBO (CN)
GAO ZHAOBO (CN)
Application Number:
PCT/CN2020/108756
Publication Date:
April 22, 2021
Filing Date:
August 13, 2020
Export Citation:
Assignee:
ZHEJIANGJIUZHOUPHARMACEUTICALCO LTD (CN)
International Classes:
C07D223/22; C07C29/143
Foreign References:
| CN101062932A | 2007-10-31 | |||
| CN101090881A | 2007-12-19 | |||
| CN102250005A | 2011-11-23 | |||
| CN102119165A | 2011-07-06 | |||
| JPH11335385A | 1999-12-07 | |||
| CN110002961A | 2019-07-12 | |||
| US20080081911A1 | 2008-04-03 |
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