Title:
PREPARATION METHOD FOR EXOSOME-LOADED POLYMER FOR USE IN ORAL COLON-TARGETING DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO/2022/142448
Kind Code:
A1
Abstract:
A preparation method for an exosome-loaded self-assembled polymer for use in oral colon-targeting drug delivery. The polymer is formed by compounding chitosan quaternary ammonium salt (HTCC), oxidized konjac glucomannan (OKGM), and a mesenchymal stem cell-derived exosome (MSCs-EXO) by means of layer-by-layer (LBL) wrapping and LBL encapsulation. The polymer has certain biocompatibility, stability, safety, anti-inflammatory, and sustained release performance, and can be used as a drug-carrying system to carry the exosome so as to repair an ulcerous part.
Inventors:
DENG CHAO (CN)
CHEN JINGHUA (CN)
HU YIWEI (CN)
KANG MINGZHU (CN)
LI MENGYU (CN)
DUAN YIDU (CN)
PAN ZIHAO (CN)
ZHANG XIADING (CN)
CHEN JINGHUA (CN)
HU YIWEI (CN)
KANG MINGZHU (CN)
LI MENGYU (CN)
DUAN YIDU (CN)
PAN ZIHAO (CN)
ZHANG XIADING (CN)
Application Number:
PCT/CN2021/116897
Publication Date:
July 07, 2022
Filing Date:
September 07, 2021
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
A61K35/28; A61K9/51; A61K47/36; A61P1/00; A61P29/00; C08B37/00; C08B37/08
Foreign References:
| CN112618515A | 2021-04-09 | |||
| CN112516107A | 2021-03-19 | |||
| CN111419874A | 2020-07-17 | |||
| US20190231694A1 | 2019-08-01 | |||
| CN105078890A | 2015-11-25 | |||
| CN109745582A | 2019-05-14 | |||
| CN109350607A | 2019-02-19 | |||
| CN111759862A | 2020-10-13 |
Other References:
YANG XIANGRONG, ET AL.: "Biological Characteristics of Exosomes Secreted by Human Umbilical Cord-derived Mesenchymal Stromal Cells", ACTA MEDICINAE UNIVERSITATIS SCIENTIAE ET TECHNOLOGIAE HUAZHONG, HUAZHONG KEJI DAXUE, TONGJI YIXUEYUAN, CN, vol. 45, no. 2, 15 April 2016 (2016-04-15), CN , pages 154 - 159, XP055947690, ISSN: 1672-0741, DOI: 10.3870/j.issn.1672-0741.2016.02.008
Attorney, Agent or Firm:
HARBIN SHINEIP INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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