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Title:
PREPARATION METHOD FOR METFORMIN HYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO/2021/012274
Kind Code:
A1
Abstract:
The present invention provides a preparation method for metformin hydrochloride. The preparation method comprises: heating raw materials comprising dicyandiamide and dimethylamine hydrochloride by means of microwave, and making the two react at 100-160°C to obtain a product system comprising metformin hydrochloride. The dicyandiamide and the dimethylamine hydrochloride are heated by means of microwave heating. Compared with a conventional heating method which requires heat to be transferred gradually from the outside to the inside, the microwave heating can directly heat a reactant to all internal parts thereof so as to make the internal temperature of the reactant more uniform, thereby reducing the generation of impurities. Therefore, the synthesis of metformin hydrochloride by means of microwave heating can improve the purity of the metformin hydrochloride, and is suitable for a melting method and a solvent method, thereby greatly reducing the production difficulty, simplifying the technological process, and providing more feasible solutions for industrialization. The preparation method is suitable for a melting method and a solvent method, thereby greatly reducing the production difficulty.

Inventors:
HONG HAO (US)
LU JIANGPING (CN)
TAO JIAN (CN)
ZHANG YAN (CN)
WANG FAN (CN)
MIGUEL GONZALEZ (US)
Application Number:
PCT/CN2019/097762
Publication Date:
January 28, 2021
Filing Date:
July 25, 2019
Export Citation:
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Assignee:
ASYMCHEM LIFE SCIENCE TIANJIN CO LTD (CN)
International Classes:
C07C279/26; C07C277/08
Domestic Patent References:
WO2014041566A22014-03-20
Foreign References:
CN108178738A2018-06-19
CN109535279A2019-03-29
Other References:
ANVAR SHALMASHI: "New Route to Metformin Hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) Synthesis", MOLBANK, MDPI, BASEL, SWITZERLAND, vol. 28, no. 1, M534, 1 March 2008 (2008-03-01), Basel, Switzerland, XP055566762, ISSN: 1422-8599, DOI: 10.3390/M564
SINGH SHAMINDER, WANJARI PRAVIN J., BHATIA SONAM, SONWANE VIJAY C., CHAKRABORTI ASIT K., BHARATAM PRASAD V.: "Design, synthesis, biological evaluation and toxicity studies of N,N-disubstituted biguanides as quorum sensing inhibitors", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON., US, vol. 24, no. 5, 1 May 2015 (2015-05-01), US, pages 1974 - 1987, XP055775121, ISSN: 1054-2523, DOI: 10.1007/s00044-014-1255-y
Attorney, Agent or Firm:
KANGXIN PARTNERS, P.C. (CN)
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