Title:
PREPARATION METHOD FOR PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/143252
Kind Code:
A1
Abstract:
Disclosed is a preparation method for a pharmaceutical composition, which is a method for obtaining a spray powder of effective sites extracts by subjecting erigeron breviscapus, ginseng, radix ophiopogonis, and fructus schisandrae to an extraction refinement method, comprising subjecting erigeron breviscapus to water extraction, alkali dissolution, and acid precipitation, the precipitate being a flavonoid compound, and spraying the powder to obtain powder 1; further removing pyromeconic acid from the acidified supernatant, enriching caffeic acid ester components, and spraying powder to obtain powder 2; enriching ginsenoside component from ginseng, subjecting radix ophiopogonis to alcohol extraction and water precipitation to enrich flavanone components in radix ophiopogonis; subjecting fructus schisandrae to water extraction, discarding the water extraction solution to remove most of organic acid components, then performing alcohol extraction, performing concentration by means of membrane filtration, and using ethyl acetate for extraction to enrich lignan components. The enriched ginsenoside components, the radix ophiopogonis flavanone components, and the fructus schisandrae lignan components are combined, powder spraying is performed to obtain powder 3; and the powders 1, 2 and 3 are mixed, or some excipients are added so as to obtain the pharmaceutical composition.
Inventors:
LIN YANHE (CN)
Application Number:
PCT/CN2021/139602
Publication Date:
July 07, 2022
Filing Date:
December 20, 2021
Export Citation:
Assignee:
YUNNAN BIOVALLEY PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K36/8968; A61P9/00; C07B63/00; C07C51/42
Foreign References:
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Other References:
ZHANG, XUXUE: "Schisandra Chinensis", MEDICINAL CHEMISTRY OF NATURAL PRODUCTS, 30 September 2012 (2012-09-30), CN, pages 174 - 176, XP009537928, ISBN: 978-7-5605-4462-5
Attorney, Agent or Firm:
BEIJING DIJIN INTELLECTUAL PROPERTY AGENCY LAW OFFICE (CN)
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