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Title:
PREPARATION METHOD FOR PYRROLOAMINOPYRIDAZINONE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/057998
Kind Code:
A1
Abstract:
The present disclosure relates to a preparation method for a pyrroloaminopyridazinone compound. Specifically, the present disclosure relates to a method for preparing a compound represented by formula (III), comprising the step of reacting a compound represented by formula (II) in the presence of an oxidizing agent, where each substituent of the compound represented by formula (II) and the compound represented by formula (III) is the same as defined in the specification. The method has a high yield, excellent product purity, and mild reaction conditions.

Inventors:
GUAN ZHONGJUN (CN)
ZHU LINGJIAN (CN)
HUANG JIAN (CN)
Application Number:
PCT/CN2020/118309
Publication Date:
April 01, 2021
Filing Date:
September 28, 2020
Export Citation:
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Assignee:
SHANGHAI SENHUI MEDICINE CO LTD (CN)
SHANGHAI SHENGDI PHARMACEUTICAL CO LTD (CN)
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
C07D403/04; C07D471/04
Domestic Patent References:
WO2019196915A12019-10-17
WO2010046780A22010-04-29
WO2018017633A12018-01-25
WO2016007185A12016-01-14
Foreign References:
CN102648183A2012-08-22
CN101282725A2008-10-08
CN108463460A2018-08-28
CN106573001A2017-04-19
CN105837576A2016-08-10
Other References:
LI FU-RONG, ZHANG YU-JUAN, GUO FENG-GUANG, DUAN GUI-YUN, GE YAN-QING: "3-(4-Bromophenyl)-1-(4-chlorobenzyl)-1 H -pyrazole-5-carbaldehyde", ACTA CRYSTALLOGRAPHICA SECTION E STRUCTURE REPORTS ONLINE, vol. 68, no. 7, 15 July 2012 (2012-07-15), pages o2203 - o2203, XP055794410, DOI: 10.1107/S1600536812027298
DADIBOYENA, S. ; VALENTE, E.J. ; HAMME, A.T.: "Synthesis of novel pyrazoles via [2+3]-dipolar cycloaddition using alkyne surrogates", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 51, no. 9, 3 March 2010 (2010-03-03), Amsterdam , NL, pages 1341 - 1343, XP026874168, ISSN: 0040-4039
LI QINGJIANG, JIANG JINGQIAN, FAN AILI, CUI YUXIN, JIA YANXING: "Total Synthesis of Lamellarins D, H, and R and Ningalin B", ORGANIC LETTERS ., AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 2, 21 January 2011 (2011-01-21), US, pages 312 - 315, XP055794415, ISSN: 1523-7060, DOI: 10.1021/ol1027877
NAYAK MALOY, BATRA SANJAY: "Synthesis of substituted pyrazolo[4,3-b]pyridines via copper-mediated intramolecular C–N cross-coupling of primary allylamines", RSC ADVANCES, vol. 2, no. 8, 1 January 2012 (2012-01-01), pages 3367, XP055794417, DOI: 10.1039/c2ra01170k
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
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