Title:
PREPARATION METHOD FOR SUCRALOSE, CRUDE PRODUCT SOLUTION, AND SUCRALOSE
Document Type and Number:
WIPO Patent Application WO/2022/141227
Kind Code:
A1
Abstract:
The present application provides a preparation method for sucralose and a crude product solution thereof. The preparation method comprises: dissolving sucralose-6-ethyl ester in methanol to form a sucralose-6-ethyl ester reaction solution; adding tert-butylamine to the sucralose-6-ethyl ester reaction solution as a catalyst for reaction under a preset condition, so that the sucralose-6-ethyl ester undergoes a deacylation reaction to form a sucralose mixed solution; and distilling the sucralose mixed solution to obtain a sucralose crude product solution. The present application has the following beneficial effects: by using volatile tert-butylamine as a catalyst, the catalyst can be removed and recycled only by means of a simple distillation process while efficiently and reliably catalyzing the deacylation reaction of the sucralose-6-ethyl ester, thereby simplifying the process step of catalyst separation, reducing material consumption and wastewater generation, and greatly reducing the production cost of sucralose; and clean production is facilitated.
Inventors:
ZHAO JINGANG (CN)
XIA JIAXIN (CN)
XU CHUANJIU (CN)
ZHOU WANQUAN (CN)
XIA JIAXIN (CN)
XU CHUANJIU (CN)
ZHOU WANQUAN (CN)
Application Number:
PCT/CN2020/141525
Publication Date:
July 07, 2022
Filing Date:
December 30, 2020
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07H5/02
Foreign References:
| CN101260127B | 2011-04-20 | |||
| CN101613379A | 2009-12-30 | |||
| CN101245085B | 2012-02-01 |
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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