Title:
PREPARATION METHOD FOR VITAMIN K1 HAVING DIFFERENT CIS-TRANS ISOMER PROPORTIONS AND INTERMEDIATE HALOGENATED PHYTOL THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/120522
Kind Code:
A1
Abstract:
Disclosed in the present invention is a preparation method for vitamin K1 having different cis-trans isomer proportions and an intermediate halogenated phytol thereof. The method comprises: carrying out a halogenation reaction on a raw material phytol and phosphorus trihalide under the catalysis of phosphoric acid to obtain halogenated phytol, reacting the halogenated phytol with cyclopentadienyl menadione, and carrying out high-temperature depolymerization to obtain vitamin K1. According to the vitamin K1 obtained by the method of the present invention, the addition amount of phosphoric acid in the halogenation reaction can be controlled, so that the proportion of the obtained vitamin K1 cis isomer can be regulated between 1% and 21%.
Inventors:
XU KUI (CN)
NIAN FUYU (CN)
XU YONGGANG (CN)
CHEN SONG (CN)
ZHANG HAONING (CN)
NIAN FUYU (CN)
XU YONGGANG (CN)
CHEN SONG (CN)
ZHANG HAONING (CN)
Application Number:
PCT/CN2020/091958
Publication Date:
June 24, 2021
Filing Date:
May 23, 2020
Export Citation:
Assignee:
NANJING HANXIN PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07C17/16; C07C21/04; C07C21/14; C07C46/00; C07C50/14
Foreign References:
| CN111153765A | 2020-05-15 |
Other References:
ZHANG ZHIGANG: "Synthesis of Vitamin K1 with Different Ratio of Cis/Trans Isomers", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 47, no. 2, 10 February 2016 (2016-02-10), pages 147 - 148+162, XP055821499, ISSN: 1001-8255, DOI: 10.16522/j.cnki.cjph.2016.02.004
YA-FEI JI, ZHI-MIN ZONG,XIAN-YONG WEI,GUANG-ZHONG TU,LI XU , LIN-TAO HE: "Improved Synthesis of Vitamin K1.", SYNTHETIC COMMUNICATIONS, vol. 33, no. 5, 1 March 2003 (2003-03-01), pages 763 - 772, XP001144631, ISSN: 0039-7911, DOI: 10.1081/SCC-120016320
YA-FEI JI, ZHI-MIN ZONG,XIAN-YONG WEI,GUANG-ZHONG TU,LI XU , LIN-TAO HE: "Improved Synthesis of Vitamin K1.", SYNTHETIC COMMUNICATIONS, vol. 33, no. 5, 1 March 2003 (2003-03-01), pages 763 - 772, XP001144631, ISSN: 0039-7911, DOI: 10.1081/SCC-120016320
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