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Patent Searching and Data


Title:
PREPARATION PROCESS FOR HYDROPHILIC SURFACE OF SUBSTRATE AND THREE-DIMENSIONAL CELL CULTURE SCAFFOLD
Document Type and Number:
WIPO Patent Application WO/2021/169590
Kind Code:
A1
Abstract:
Disclosed in the present invention is a preparation process for a hydrophilic surface of a substrate, and a three-dimensional cell culture scaffold. The preparation process for the hydrophilic surface of a substrate comprises the following steps: S1, corona treatment: performing corona treatment on a polymer substrate to cause the polymer substrate to obtain an initial hydrophilic surface; S2, microwave treatment: performing microwave treatment on a gas mixture, and ionizing to produce active particles; S3, plasma treatment: using the active particles obtained in step S2 to perform plasma treatment on the polymer substrate having an initial hydrophilic surface obtained in S1, to cause the polymer substrate to obtain an oxygen-rich super-hydrophilic surface. The three-dimensional cell culture scaffold comprises a polymer scaffold, the polymer scaffold having been surface treated by means of the hydrophilic substrate surface preparation process. The hydrophilic substrate surface preparation process of the present invention is able to cause inner and outer layer scaffold surfaces of a cell culture scaffold product of a three-dimensional structure to acquire a uniform and sustained hydrophilicity to improve the adherence rate and the survival rate on the cell scaffold.

Inventors:
LI HUILUN (CN)
FANG XIANGYUAN (CN)
YUAN YE JAMES (CN)
YUAN JIANHUA (CN)
Application Number:
PCT/CN2020/142059
Publication Date:
September 02, 2021
Filing Date:
December 31, 2020
Export Citation:
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Assignee:
GUANGZHOU JET BIOFILTRATION CO LTD (CN)
International Classes:
C08J7/12; C12N5/00
Foreign References:
CN111286066A2020-06-16
CN107434853A2017-12-05
CN102046779A2011-05-04
US7579179B22009-08-25
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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