Title:
PREVENTATIVE OR THERAPEUTIC AGENT FOR TAUOPATHY
Document Type and Number:
WIPO Patent Application WO/2021/079887
Kind Code:
A1
Abstract:
The present invention provides a preventative or therapeutic agent for tauopathy, that contains an α2δ inhibitor for voltage-gated calcium channels.
Inventors:
INOUE HARUHISA (JP)
IMAMURA KEIKO (JP)
HIGUCHI MAKOTO (JP)
SAHARA NARUHIKO (JP)
ONO MAIKO (JP)
IMAMURA KEIKO (JP)
HIGUCHI MAKOTO (JP)
SAHARA NARUHIKO (JP)
ONO MAIKO (JP)
Application Number:
PCT/JP2020/039450
Publication Date:
April 29, 2021
Filing Date:
October 20, 2020
Export Citation:
Assignee:
UNIV KYOTO (JP)
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
International Classes:
A61K45/00; A61K31/197; A61P25/28; G01N33/15; G01N33/50
Domestic Patent References:
| WO2010060100A2 | 2010-05-27 | |||
| WO2009041453A1 | 2009-04-02 | |||
| WO2011026031A1 | 2011-03-03 |
Foreign References:
| JP2008013555A | 2008-01-24 | |||
| JP2010536852A | 2010-12-02 | |||
| JP2005529941W | ||||
| JPS5188940A | 1976-08-04 | |||
| JP2000034226A | 2000-02-02 | |||
| US5223409A | 1993-06-29 | |||
| US5571698A | 1996-11-05 | |||
| US5403484A | 1995-04-04 | |||
| US20020103360A1 | 2002-08-01 | |||
| JP2019194758A | 2019-11-07 |
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ELINOR J. GRIFFITHS ET AL.: "Inhibition of mitochondrial calcium efflux by clonazepam in intact single rat cardiomyocytes and effects on NADH production", CELL CALCIUM, vol. 21, no. 4, 1997, pages 321 - 329
HENDRICH J ET AL.: "Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin", PROC NATL ACADSCI USA, vol. 105, 2008, pages 3628 - 33
SANTACRUZ, K. ET AL., SCIENCE, vol. 309, 2005, pages 476 - 481
REDA, H.M. ET AL., EUR J PHARMACOL, vol. 771, 2016, pages 162 - 172
TAGAI ET AL., MEDRXIV, 2020
IMAMURA, K. ET AL.: "Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons", SCI. REP., vol. 6, 2016, pages 34904 - 34913
LEE V.M. ET AL., ANNU. REV. NEUROSCI., vol. 24, 2001, pages 1121 - 159
HUTTON, M. ET AL.: "Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17", NATURE, vol. 393, 1998, pages 702 - 705
BAUER CS ET AL.: "A new look at calcium channel α2δ subunits", CURR OPIN NEUROBIOL., vol. 20, 2010, pages 563 - 71, XP027325980
DOLPHIN A.C., BIOCHIM BIOPHYSACTA., vol. 1828, no. 7, 2013, pages 1541 - 9
DAVIES A. ET AL., TRENDS PHARMACOL SCI., vol. 28, no. 5, 2007, pages 220 - 8
TUERK, C.GOLD, L., SCIENCE, vol. 249, 1990, pages 404 - 510
ELBASHIR ET AL., GENES DEV., vol. 15, 2001, pages 188 - 200
LAM, ANTICANCER DRUG DES, vol. 12, 1997, pages 145 - 67
DEWITT ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6909 - 13
ERB ET AL., PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 11422 - 6
ZUCKERMANN ET AL., J. MED. CHEM., vol. 37, 1994, pages 1233 - 51
CHO ET AL., SCIENCE, vol. 261, 1993, pages 1303 - 5
CARELL ET AL., ANGEW. CHEM. INT. ED. ENGL., vol. 33, 1994, pages 2061
HOUGHTEN, BIO/TECHNIQUES, vol. 13, 1992, pages 412 - 21
LAM, NATURE, vol. 354, 1991, pages 82 - 4
FODOR, NATURE, vol. 364, 1993, pages 555 - 6
CULL, PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 1865 - 9
CWIRLA ET AL., PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 6378 - 82
FELICI, J. MOL. BIOL., vol. 222, 1991, pages 301 - 10
"GABAPEN Tablets Pharmaceutical Interview Form Revised", April 2017
E KEPPRA: "Carbamazepine Tablets Pharmaceutical Interview Form Revised", June 2018
DEPAKENE TABLETS PHARMACEUTICAL INTERVIEW FORM REVISED, July 2019 (2019-07-01)
ELINOR J. GRIFFITHS ET AL.: "Inhibition of mitochondrial calcium efflux by clonazepam in intact single rat cardiomyocytes and effects on NADH production", CELL CALCIUM, vol. 21, no. 4, 1997, pages 321 - 329
HENDRICH J ET AL.: "Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin", PROC NATL ACADSCI USA, vol. 105, 2008, pages 3628 - 33
SANTACRUZ, K. ET AL., SCIENCE, vol. 309, 2005, pages 476 - 481
REDA, H.M. ET AL., EUR J PHARMACOL, vol. 771, 2016, pages 162 - 172
TAGAI ET AL., MEDRXIV, 2020
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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