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Title:
PREVENTIVE OR THERAPEUTIC AGENTS FOR INFLAMMATORY DERMATOSES
Document Type and Number:
WIPO Patent Application WO/2000/054778
Kind Code:
A1
Abstract:
Novel medicinal uses of 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, optical isomers of the same, or pharmacologically acceptable salts of both. The oral administration of the preventive or therapeutic agents brings about decrease in the dosage of steroid external preparations, thus leading to safe and efficacious medications for the prevention or treatment of inflammatory dermatoses.

Inventors:
YAMAGUCHI SHUJI (JP)
TOMOMATSU NORIKO (JP)
KOMATSU HIROTSUGU (JP)
Application Number:
PCT/JP2000/001409
Publication Date:
September 21, 2000
Filing Date:
March 08, 2000
Export Citation:
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Assignee:
YOSHITOMI PHARMACEUTICAL (JP)
YAMAGUCHI SHUJI (JP)
TOMOMATSU NORIKO (JP)
KOMATSU HIROTSUGU (JP)
International Classes:
A61K31/5517; A61P17/00; A61P29/00; (IPC1-7): A61K31/5517; A61P17/00; A61P29/00; C07D495/14
Foreign References:
JPH01156982A1989-06-20
Other References:
YAMAGUCHI, S. ET. AL.: "Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice.", INFLAMMATION RESEARCH, vol. 47, no. 12, 1998, pages 506 - 511, XP002928856
OKAMOTO H. ET. AL.: "Suppression of the Arthur reaction by Y-21480, a potent and specific antagonist of platelet activating factor.", AGENTS ACTIONS, vol. 35, no. 3-4, 1992, pages 149 - 158, XP002928857
YAMAGUCHI SHUJI ET. AL.: "Effects of Y-21480, a receptor antagonist to platelet-activating factor, on allergic cutaneus eosinophilia in mice.", LIFE SCIENCES, vol. 64, no. 11, 1999, pages 139 - 144, XP002928858
Attorney, Agent or Firm:
Takashima, Hajime (Fushimimachi 4-chome Chuo-ku Osaka-shi, Osaka, JP)
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