Title:
PROBE FOR DETECTING CARBAPENEM-RESISTANT BACTERIA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/027553
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by chemical formula 1, a probe, comprising the compound, for detecting antibiotic-resistant bacteria, a composition comprising the compound, a kit comprising the compound, and a method for detecting antibiotic-resistant bacteria. A compound probe bearing a structure of carbapenem and comprising a linker and a phosphor can detect beta-lactamase or carbapenemase at high sensitivity and, as such, can be applied to various biochemical studies. In addition, the compound probe is able to clinically detect bacteria resistant to carbapenemase-producing antibiotics and allows the molecular diagnosis of antibiotic-resistant bacterial infection disease and the analysis of antibiotic-resistant bacteria from a target sample at high sensitivity, thereby finding advantageous applications in medicinal uses such as in vitro diagnosis.
Inventors:
MIN SUN JOON (KR)
PARK YEON JOON (KR)
KIM JU HYEON (KR)
PARK YEON JOON (KR)
KIM JU HYEON (KR)
Application Number:
PCT/KR2019/009495
Publication Date:
February 06, 2020
Filing Date:
July 30, 2019
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
C12Q1/04; C09B19/00; C09B57/00; C09K11/06; C12Q1/34
Domestic Patent References:
| WO2016188998A1 | 2016-12-01 | |||
| WO1999062907A1 | 1999-12-09 | |||
| WO2017158616A1 | 2017-09-21 |
Foreign References:
| CN106279178A | 2017-01-04 |
Other References:
MAO, W. ET AL.: "Detection of Carbapenemase-Producing Organisms with a Carbapenem Based Fluorogenic Probe", ANGEW. CHEM. INI. ED., vol. 56, 2017, pages 4468 - 4472, XP055507740, DOI: 10.1002/anie.201612495
Attorney, Agent or Firm:
DAHAI INTERNATIONAL PATENT & LAW FIRM (KR)
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