Title:
PROCESS FOR THE PREPARATION OF POLYSACCHARIDES
Document Type and Number:
WIPO Patent Application WO/2014/140626
Kind Code:
A3
Abstract:
The present invention relates to a process for the preparation of polysaccharides of 8 or more monosaccharide residues in length and polysaccharides accessible by these processes, the process comprising coupling a chain extending polysaccharide of four monosaccharide residues in length with a first polysaccharide of four or more monosaccharide residues in length. The coupling proceeds by substitution of a thio leaving group (such as -SR1) bonded to the anomeric carbon of a monosaccharide residue in either the chain extending polysaccharide or the first polysaccharide.
Inventors:
GARDINER JOHN (GB)
JAYSON GORDON (GB)
MILLER GAVIN (GB)
HANSON STEEN (GB)
JAYSON GORDON (GB)
MILLER GAVIN (GB)
HANSON STEEN (GB)
Application Number:
PCT/GB2014/050806
Publication Date:
November 06, 2014
Filing Date:
March 14, 2014
Export Citation:
Assignee:
UNIV MANCHESTER (GB)
International Classes:
C07H15/04; C07H15/18; C08B37/00
Foreign References:
| JPH0489801A | 1992-03-24 |
Other References:
FRANÇOISE BALEUX ET AL: "A synthetic CD4-heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry", NATURE CHEMICAL BIOLOGY, vol. 5, no. 10, 1 October 2009 (2009-10-01), pages 743 - 748, XP055003411, ISSN: 1552-4450, DOI: 10.1038/nchembio.207
STEEN U. HANSEN ET AL: "First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide", ORGANIC LETTERS, vol. 15, no. 1, 4 January 2013 (2013-01-04), pages 88 - 91, XP055126342, ISSN: 1523-7060, DOI: 10.1021/ol303112y
BOURGEAUX E ET AL: "General access to asymmetric gamma-cyclodextrins for gas chromatographic applications by insertion of a selectively modified sugar unit", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 11, no. 20, 20 October 2000 (2000-10-20), pages 4189 - 4205, XP004221072, ISSN: 0957-4166, DOI: 10.1016/S0957-4166(00)00396-7
STEEN U. HANSEN ET AL: "Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies", NATURE COMMUNICATIONS, vol. 4, 5 July 2013 (2013-07-05), XP055126345, DOI: 10.1038/ncomms3016
STEEN U. HANSEN ET AL: "First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide", ORGANIC LETTERS, vol. 15, no. 1, 4 January 2013 (2013-01-04), pages 88 - 91, XP055126342, ISSN: 1523-7060, DOI: 10.1021/ol303112y
BOURGEAUX E ET AL: "General access to asymmetric gamma-cyclodextrins for gas chromatographic applications by insertion of a selectively modified sugar unit", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 11, no. 20, 20 October 2000 (2000-10-20), pages 4189 - 4205, XP004221072, ISSN: 0957-4166, DOI: 10.1016/S0957-4166(00)00396-7
STEEN U. HANSEN ET AL: "Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies", NATURE COMMUNICATIONS, vol. 4, 5 July 2013 (2013-07-05), XP055126345, DOI: 10.1038/ncomms3016
Attorney, Agent or Firm:
WEBSTER, Jeremy et al. (33 Gutter LaneLondon, Greater London EC2V 8AS, GB)
Download PDF:
Previous Patent: AUTOMATED TUNING FOR MALDI ION IMAGING
Next Patent: DATA DIRECTED STORAGE OF IMAGING MASS SPECTRA
Next Patent: DATA DIRECTED STORAGE OF IMAGING MASS SPECTRA