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Title:
PROCESS FOR THE PREPARATION OF TELITHROMYCIN
Document Type and Number:
WIPO Patent Application WO2005105821
Kind Code:
A3
Abstract:
The present invention relates to the process for the preparation of compounds of formula (I) or its pharmaceutically acceptable salts.The novel compounds (i) 10,11-Anhydro-2',4"-di-O-benzoyl-12-O-imidazolylcarbonyl-6-O-methylerythromycin A of formula (Xa) (ii) 2',4"-di-O-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-6-O- methylerythromycin A 11,12-cyclic carbamate of formula (XIa) (iii) 2'-O-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-5-O-desosaminyl- 6-O-methylerythronolide A 11,12-cyclic carbamate of formula (XIIa) (iv) 2'-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-5-O- desosaminyl-6-O-methylerythronolide A 11,12-cyclic carbamate of formula (XIIa) and their use as intermediates in formation of compound of Formula (I). Also the process of preparation of compound of formula (XIIIa).

Inventors:
SOHANI SUHAS (IN)
DEODHAR MANDAR (IN)
PATEL NISHANT (IN)
PATEL MANISH (IN)
DAVADRA MAHESH (IN)
KANSAL VINODKUMAR (IN)
Application Number:
PCT/IN2005/000125
Publication Date:
April 27, 2006
Filing Date:
April 25, 2005
Export Citation:
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Assignee:
ALEMBIC LTD (IN)
SOHANI SUHAS (IN)
DEODHAR MANDAR (IN)
PATEL NISHANT (IN)
PATEL MANISH (IN)
DAVADRA MAHESH (IN)
KANSAL VINODKUMAR (IN)
International Classes:
C07H17/00; C07H17/08; (IPC1-7): C07H17/08
Foreign References:
US5635485A1997-06-03
FR2732684A11996-10-11
EP0487411A11992-05-27
Other References:
WU, YONG-JIN ET AL: "Recent developments on ketolides and macrolides", CURRENT MEDICINAL CHEMISTRY , 8(14), 1727 - 1758 CODEN: CMCHE7; ISSN: 0929-8673, 2001, XP009056485
GRAUL, A. ET AL: "HMR-3647, an antimicrobial ketolide", DRUGS OF THE FUTURE , 23(6), 591-597 CODEN: DRFUD4; ISSN: 0377-8282, 1998, XP000909275
DENIS, ALEXIS ET AL: "Synthesis and antibacterial activity of HMR 3647, a new ketolide highly potent against erythromycin-resistant and susceptible pathogens", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 9(21), 3075-3080 CODEN: BMCLE8; ISSN: 0960-894X, 1999, XP004181010
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