Title:
PROCESS FOR PREPARING ANTIFUNGAL V-28-3M
Document Type and Number:
WIPO Patent Application WO/1998/055492
Kind Code:
A1
Abstract:
An industrializable process for preparing V-28-3M useful as an antifungal by methylating V-28-3 efficiently. The process comprises protecting the amino group of the amino sugar moiety of V-28-3 with a suitable protective group, methylating the carboxyl group of V-28-3 with methyl methanesulfonate or p-toluenesulfonate in the presence of a base, and removing the amino protective group of the resultant methyl ester.
Inventors:
KATAOKA NORIYASU (JP)
TANAKA KENZO (JP)
YATAGAI MASANOBU (JP)
TANAKA KENZO (JP)
YATAGAI MASANOBU (JP)
Application Number:
PCT/JP1998/002439
Publication Date:
December 10, 1998
Filing Date:
June 02, 1998
Export Citation:
Assignee:
AJINOMOTO KK (JP)
KATAOKA NORIYASU (JP)
TANAKA KENZO (JP)
YATAGAI MASANOBU (JP)
KATAOKA NORIYASU (JP)
TANAKA KENZO (JP)
YATAGAI MASANOBU (JP)
International Classes:
C07H17/08; (IPC1-7): C07H17/08
Domestic Patent References:
WO1988002004A1 | 1988-03-24 | |||
WO1988000201A1 | 1988-01-14 |
Foreign References:
EP0285805A2 | 1988-10-12 | |||
JPH04145066A | 1992-05-19 | |||
JPS6456683A | 1989-03-03 | |||
JPS50129531A | 1975-10-13 |
Other References:
See also references of EP 0987273A4
Attorney, Agent or Firm:
Hagino, Taira (28th floor ARK Mori Building, 12-32, Akasaka 1-chom, Minato-ku Tokyo, JP)
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