Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PROCESS FOR PREPARING LIPID II AND DERIVATIVES THEREOF
Document Type and Number:
WIPO Patent Application WO2001079242
Kind Code:
A3
Abstract:
A process is described for preparing a substrate for the transglycosylase enzymes of bacterial cell wall biosynthesis. The chemical synthesis makes available a sustainable and substantially pure source of supply of lipid II, including analogs thereof, that maybe used in the identification of new therapeutic agents capable of disrupting steps in bacterial cell wall biosynthesis.

Inventors:
ALBORN WILLIAM ERNEST JR
BLASZCZAK LARRY CHRIS
MAULDIN SCOTT CARL
SKATRUD PAUL LUTHER
VANNIEUWENHZE MICHAEL SCOTT
ZIA-EBRAHIMI MOHAMMAD SADEGH
Application Number:
PCT/US2001/012637
Publication Date:
June 06, 2002
Filing Date:
April 18, 2001
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
LILLY CO ELI (US)
International Classes:
C07K7/02; C07H15/04; C07K4/00; C07K5/02; C07K9/00; (IPC1-7): C07K9/00
Other References:
MEN H ET AL: "SUBSTRATE SYNTHESIS AND ACTIVITY ASSAY FOR MURG", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 120, no. 10, 1998, pages 2484 - 2485, XP000919200, ISSN: 0002-7863
AUGER G ET AL: "SYNTHESIS OF AN ANALOGUE OF THE LIPOGLYCOPEPTIDE MEMBRANE INTERMEDIATE I OF PEPTIDOGLYCAN BIOSYNTHESIS", LETTERS IN PEPTIDE SCIENCE, ESCOM SCIENCE PUBLISHERS, NL, vol. 4, 1997, pages 371 - 376, XP002920364, ISSN: 0929-5666
HA, S., CHANG E., LO, M-C., MEN H., PARK P., GE M., WALKER S.: "THE KINETIC CHARACTERIZATION OF ESCHERICHIA COLI MurG USING SYNTHETIC SUBSTRATE ANALOGUES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 121, no. 37, 22 September 1999 (1999-09-22), pages 8415 - 8426, XP002183381
Download PDF: