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Title:
PROCESS FOR PREPARING NETILMICIN
Document Type and Number:
WIPO Patent Application WO1987002365
Kind Code:
A3
Abstract:
A high yielding process for converting 3,2',6'-tri-N-acetyl sisomicin to netilmicin comprising the step of silylating the starting material at the 5,2" positions, and optionally at the 4" position, converting the 1-amino substituents to a 1-N-imino substituent, converting the imino to an ethylamino, deprotecting the compound and recovering netilmicin. Also disclosed are novel intermediate compounds.

Inventors:
TANN CHOU-HONG (US)
THIRUVENGADAM TIRUVETTIPURAM K (US)
CHIU JOHN SZE-HUNG (US)
COLON CESAR (US)
Application Number:
PCT/US1986/002122
Publication Date:
August 27, 1987
Filing Date:
October 14, 1986
Export Citation:
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Assignee:
SCHERING CORP (US)
International Classes:
C07H1/00; A61K31/70; A61K31/7028; A61K31/7034; A61K31/7036; A61K31/7135; A61P31/04; C07H15/236; C07H17/04; C07H23/00; C07H; (IPC1-7): C07H15/236
Foreign References:
CA1034573A1978-07-11
CA1034573A1978-07-11
US4230847A1980-10-28
US4230847A1980-10-28
EP0021215A11981-01-07
EP0021215A11981-01-07
Other References:
See also references of EP 0242385A1
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