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Title:
PROCESS FOR PREPARING WATER-SOLUBLE PHOSPHONOOXYMETHYL DERIVATIVES OF ALCOHOL AND PHENOL
Document Type and Number:
WIPO Patent Application WO2003059255
Kind Code:
A3
Abstract:
A process for making water-soluble phosphonooxymethyl ethers of hindered alcohol and phenol containing pharmaceuticals, such as camptothecin, propofol, etoposide, Vitamin E and Cyclosporin A. In particular, the process for preparing water-soluble phosphonooxymethyl derivatives comprises the steps of Formula (i) and Formula (ii); R-OH represents an alcohol- or phenol-containing drug, n represents an integer of 1 or 2, R<1> is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation, and R<2> is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation.

Inventors:
BONNEVILLE GEORGE (US)
DELAHANTY GREG (US)
WALZ ANDREW J (US)
Application Number:
PCT/US2002/040748
Publication Date:
February 19, 2004
Filing Date:
December 20, 2002
Export Citation:
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Assignee:
GUILFORD PHARM INC (US)
BONNEVILLE GEORGE (US)
DELAHANTY GREG (US)
WALZ ANDREW J (US)
International Classes:
C07H17/04; A61K31/663; A61K31/665; A61K31/675; A61K31/7048; A61K38/00; A61P3/02; A61P23/00; A61P35/00; A61P37/02; C07F9/09; C07F9/6515; C07F9/655; C07F9/6561; C07K7/64; (IPC1-7): A61K31/66
Foreign References:
US6204257B12001-03-20
Other References:
See also references of EP 1471920A4
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