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Title:
PROCESS FOR PRODUCING ERYTHROMYCIN DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2002/014339
Kind Code:
A1
Abstract:
A method of introducing a 6-position substituent into a 6,9-cyclic acetal of a 5-O-desosaminylerythronolide derivative, characterized by cleaving the cyclic acetal selectively at the 9-position C-O bond; and a process for efficiently synthesizing a 6-O-substituted ketolide derivative which comprises a combination of conversion of each of the 9- and 3-position substituents into a carbonyl group and formation of a 11,12-cyclic carbamate.

Inventors:
KASHIMURA MASATO (JP)
KAMIYAMA HIROAKI (JP)
KUWADA TAKESHI (JP)
SUZUKI NOBUYUKI (JP)
ADACHI TAKASHI (JP)
Application Number:
PCT/JP2001/006928
Publication Date:
February 21, 2002
Filing Date:
August 10, 2001
Export Citation:
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Assignee:
TAISHO PHARMA CO LTD (JP)
KASHIMURA MASATO (JP)
KAMIYAMA HIROAKI (JP)
KUWADA TAKESHI (JP)
SUZUKI NOBUYUKI (JP)
ADACHI TAKASHI (JP)
International Classes:
C07H17/08; (IPC1-7): C07H17/08; C07H1/00
Domestic Patent References:
WO1999016779A11999-04-08
WO1999011651A21999-03-11
WO2000078773A22000-12-28
Foreign References:
JP2001072699A2001-03-21
Other References:
See also references of EP 1310506A4
Attorney, Agent or Firm:
Asamura, Kiyoshi (New Ohtemachi Bldg. 2-, Ohtemachi 2-chome Chiyoda-ku Tokyo, JP)
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