Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PROCESS FOR PRODUCTION OF (3S)-3-HYDROXYMETHYL-7-OXO- PYRIDOBENZOXAZINE-6-CARBOXYLIC ESTERS
Document Type and Number:
WIPO Patent Application WO/2006/009143
Kind Code:
A1
Abstract:
The invention provides an industrially advantageous process for the production of (3S)-3-hydroxymethyl-7- oxopyridobenzoxazine-6-carboxylic ester derivatives useful as intermediates of (3R)-3-fluoromethyl-7-oxopyridobenzoxazine -6-carboxylic acid derivatives having 4-substituted-3-cyclo- propylaminomethylpyrrolidinyl groups which serve as antimicrobial agents. The process is represented by the following reaction scheme: (X) wherein R1 is hydrogen, fluoro, or lower alkyl; R2 is lower alkyl; X is hydrogen or halogeno; and Y is halogeno.

Inventors:
ASAHINA YOSHIKAZU (JP)
KIMURA TETSUYA (JP)
Application Number:
PCT/JP2005/013251
Publication Date:
January 26, 2006
Filing Date:
July 19, 2005
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KYORIN SEIYAKU KK (JP)
ASAHINA YOSHIKAZU (JP)
KIMURA TETSUYA (JP)
International Classes:
C07D498/06; C07B53/00; C07M7/00; (IPC1-7): C07D498/06; C07B53/00; C07M7:00
Domestic Patent References:
WO2003078439A12003-09-25
Foreign References:
JPS62452A1987-01-06
JPS62252772A1987-11-04
JPS62198685A1987-09-02
JPS591489A1984-01-06
Other References:
ATARASHI S. ET AL: "Synthesis and Antibacterial Activities of Optically Active Ofloxacin and its Fluoromethyl Derivative.", CHEM PHARM BULL., vol. 35, no. 5, 1987, pages 1896 - 1902, XP002991710
GREENE W. ET AL, PROTECTIVE GROUPS IN ORGANIC SYNTHESIS, 3RD EDITION., 1991, pages 31 - 34, XP002991711
Attorney, Agent or Firm:
Kishida, Masayuki (2-3 Marunouchi 2-chom, Chiyoda-ku Tokyo 05, JP)
Download PDF:



 
Previous Patent: STEEL FOR STEEL PIPE

Next Patent: VACUUM HEAT INSULATION MATERIAL