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Title:
PROCESS FOR THE RACEMISATION OF ENANTIOMERICALLY ENRICHED ALPHA-AMINO NITRILES
Document Type and Number:
WIPO Patent Application WO2004046088
Kind Code:
A8
Abstract:
Process for the racemisation of an enantiomerically enriched alpha-amino nitrile characterized in that the enantiomerically enriched alpha-amino nitrile is contacted with a lewis acid catalyst. Preferably an aprotic solvent is used. The lewis acid catalyst preferably comprises a metal chosen from main group elements IA-IVA of the Periodic Table (CAS version), the transition metals and the lanthanides, in particular Al, Ti, Zr, or lanthanides. The catalsyt for example has the general structure MnXpSqLr, and preferably is chosen from the group of aluminum alkoxides, aluminum alkyls, lanthanide alkoxydes and lanthanocenes. The racemisation may be performed in combination with a resolution process, for instance in combination with an enzymatic or a crystallization induced resolution process, preferably in situ, for instance in situ in a crystallization induced asymmetric transformation process.

Inventors:
VERZIJL GERARDUS KAREL MARIA (NL)
KAPTEIN BERNARDUS (NL)
BROXTERMAN QUIRINUS BERNARDUS (NL)
Application Number:
PCT/EP2003/012412
Publication Date:
September 29, 2005
Filing Date:
November 03, 2003
Export Citation:
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Assignee:
DSM IP ASSETS BV (NL)
VERZIJL GERARDUS KAREL MARIA (NL)
BROXTERMAN QUIRINUS BERNARDUS (NL)
International Classes:
C07C253/30; C07C255/24; C07C255/42; C07C255/44; (IPC1-7): C07C253/30; C07C255/24; C07C255/42; C07C255/44
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