Title:
PROCESSES FOR THE PRODUCTION OF AMINOALKYL GLUCOSAMINIDE PHOSPHATE AND DISACCHARIDE IMMUNOEFFECTORS, AND INTERMEDIATES THEREFOR
Document Type and Number:
WIPO Patent Application WO2004005308
Kind Code:
A3
Abstract:
This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.
Inventors:
JOHNSON DAVID A (US)
JOHNSON CRAIG L (US)
BAZIN-LEE HELENE G (US)
SOWELL C GREGORY (US)
JOHNSON CRAIG L (US)
BAZIN-LEE HELENE G (US)
SOWELL C GREGORY (US)
Application Number:
PCT/US2003/021504
Publication Date:
April 22, 2004
Filing Date:
July 08, 2003
Export Citation:
Assignee:
CORIXA CORP (US)
JOHNSON DAVID A (US)
JOHNSON CRAIG L (US)
BAZIN-LEE HELENE G (US)
SOWELL C GREGORY (US)
JOHNSON DAVID A (US)
JOHNSON CRAIG L (US)
BAZIN-LEE HELENE G (US)
SOWELL C GREGORY (US)
International Classes:
C07H5/02; C07H9/02; C07H11/04; C07H13/04; C07H13/06; C07H15/04; (IPC1-7): C07H15/04; C07H5/02; C07H11/04; C07H13/04
Domestic Patent References:
| WO2002012258A1 | 2002-02-14 |
Foreign References:
| US6013640A | 2000-01-11 | |||
| US6355257B1 | 2002-03-12 | |||
| US5597573A | 1997-01-28 | |||
| EP0172581A2 | 1986-02-26 |
Other References:
GROSS, H.: "Dichlormethyl-methylether als Reagens für die organische Synthese und Kohlenhydratchemie", Z. CHEMIE, vol. 18, no. 6, 1978, pages 201 - 210, XP009019646
MAGNUSSON, G. ET AL.: "2-(Trimethylsilyl)ethyl Glycosides. Transformation into Glycopyranosyl Chlorides", J. ORG. CHEM., vol. 55, 1990, pages 3181 - 3185, XP002079515
POZSGAY, V. ET AL.: "Synthesis of Kojidextrins and their Protein Conjugates. Incidence of Steric Mismatch in Oligosaccharide Synthesis", J. ORG. CHEM., vol. 62, 1997, pages 2832 - 2846, XP002258956
KOELLER, KATHRYN M. ET AL: "Chemoenzymatic synthesis of sialyl-trimeric-Lewis X", CHEMISTRY--A EUROPEAN JOURNAL (2000), 6(7), 1243-1251, 2000, XP001157171
MAGNUSSON, G. ET AL.: "2-(Trimethylsilyl)ethyl Glycosides. Transformation into Glycopyranosyl Chlorides", J. ORG. CHEM., vol. 55, 1990, pages 3181 - 3185, XP002079515
POZSGAY, V. ET AL.: "Synthesis of Kojidextrins and their Protein Conjugates. Incidence of Steric Mismatch in Oligosaccharide Synthesis", J. ORG. CHEM., vol. 62, 1997, pages 2832 - 2846, XP002258956
KOELLER, KATHRYN M. ET AL: "Chemoenzymatic synthesis of sialyl-trimeric-Lewis X", CHEMISTRY--A EUROPEAN JOURNAL (2000), 6(7), 1243-1251, 2000, XP001157171
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