PROCESSES FOR PRODUCTION OF (R)-3-[4-(TRIFLUOROMETHYL)- PHENYLAMINO]PENTANAMIDE DERIVATIVES

Title:

PROCESSES FOR PRODUCTION OF (R)-3-[4-(TRIFLUOROMETHYL)- PHENYLAMINO]PENTANAMIDE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2004/083166

Kind Code:

A1

Abstract:

The invention provides processes by which (R)-3-[4- (trifluoromethyl)phenylamino]pentanamide derivatives useful as intermediates of drugs, particularly, cholesteryl ester transfer protein (CETP) inhibitor can be easily and simply produced from easily available starting materials. According to the invention, (S)-N-[4-(trifluoromethyl)- phenyl]-3-hydroxypentanamide is produced from easily available raw materials and converted into (R)-3-[4-(trifluoromethyl)- phenylamino]pentanamide through (R)-4-ethyl-1-[4-(trifluoro- methyl)phenyl]-2-azetidinone. Further, (R)-3-[4-(trifluoro- methyl)phenylamino]pentanamide derivatives are produced by reacting (R)-4-ethyl-1-[4-trifluoromethyl]phenyl]-2- azetidinone with a carbamic acid ester.

Inventors:

TANAKA TATSUYOSHI (JP)
SUGAWARA MASANOBU (JP)
MAEDA HIROFUMI (JP)
NISHIYAMA AKIRA (JP)
YASOHARA YOSHIHIKO (JP)
NAGASHIMA NOBUO (JP)

Application Number:

PCT/JP2004/003535

Publication Date:

September 30, 2004

Filing Date:

March 17, 2004

Export Citation:

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Assignee:

KANEKA CORP (JP)
TANAKA TATSUYOSHI (JP)
SUGAWARA MASANOBU (JP)
MAEDA HIROFUMI (JP)
NISHIYAMA AKIRA (JP)
YASOHARA YOSHIHIKO (JP)
NAGASHIMA NOBUO (JP)

International Classes:

C07C231/02; C07C231/10; C07C231/18; C07C235/16; C07C303/28; C07C309/66; C07C309/73; C07D205/08; C07C237/06; C07C237/52; (IPC1-7): C07C269/06; C07C231/02; C07C235/16; C07C237/06; C07C269/04; C07C271/64; C07C303/44; C07C309/66; C07C309/73; C07D205/08

Domestic Patent References:

WO2002088069A2	2002-11-07
WO2002088085A2	2002-11-07

Other References: