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Patent Searching and Data


Title:
A PRODRUG PLATFORM USEFUL TO DELIVER AMINES, AMIDES AND PHENOLS
Document Type and Number:
WIPO Patent Application WO/2021/032075
Kind Code:
A1
Abstract:
Provided herein is a prodrug platform useful to deliver pharmaceutically active amines, amides and phenols and their use in the diagnosis, prevention and/or treatment of various diseases. Compared with the parent drug (e.g., Gemcitabine), the prodrugs show a significant overall safety improvement (therapeutic index (TI) improvement), especially in liver.

Inventors:
XU MINGYAN (CN)
Application Number:
PCT/CN2020/109698
Publication Date:
February 25, 2021
Filing Date:
August 18, 2020
Export Citation:
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Assignee:
SHANGHAI CHANGCHENGYIYAOKEJI COMPANY LTD (CN)
International Classes:
C07H19/06; A61K31/7068; A61P35/00; C07F9/6574; C07H19/11
Domestic Patent References:
WO2020001475A12020-01-02
WO2019120299A12019-06-27
WO2001018013A12001-03-15
Other References:
ERION M.D.: "Design, Synthesis, and Characterization of a Series of Cytochrome P450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver;", J. AM. CHEM. SOC.;, vol. 126, no. 16, 4 February 2004 (2004-02-04), pages 5154 - 5163, XP002628532
HUTTUNEN, KRISTIINA M.; LEPP�NEN, JUKKA; KEMPPAINEN, EEVA; PALONEN, PIIA; RAUTIO, JARKKO; J�RVINEN, TOMI; VEPS�L�INEN, JOUKO:: "Towards Metformin Prodrugs", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE., vol. 2008, no. 22, 1 September 2008 (2008-09-01), STUTTGART, DE., pages 3619 - 3624, XP008152150, ISSN: 0039-7881, DOI: 10.1055/s-0028-1083603
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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