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Title:
PRODUCTION METHOD FOR AC-225 SOLUTION AND PRODUCTION METHOD FOR MEDICINE USING AC-225 SOLUTION
Document Type and Number:
WIPO Patent Application WO/2022/149578
Kind Code:
A1
Abstract:
One embodiment of the present invention relates to a production method for an 225Ac solution and a production method for a medicine using said solution. The production method for the 225Ac solution, which can be used to produce a medicine, includes: a step for irradiating a 226Ra target with particles to generate two or more kinds of actinium radioisotopes (Ac) including at least 225Ac; a step for, after the aforementioned step, dissolving the 226Ra target to obtain a solution (1) containing 226Ra and Ac; a step for separating the 226Ra and Ac included in the solution (1) to obtain a solution (2) having an increased Ac concentration as compared to solution (1); a step for disintegrating Ac other than the 225Ac included in the solution (2) to obtain a solution (3) including isotopes of radium (Ra) that have been obtained through disintegration; and a step for separating Ra and Ac included in solution (3) to obtain a solution (4) having an increased 225Ac concentration as compared to solution (3), wherein the solution (4) contains, as an active component, a composite of a 225Ac-complexed chelating agent and an Nd2 antibody or a targeting agent (other than an Nd2 antibody).

Inventors:
HONDA YOSHIO (JP)
ITO TAKU (JP)
ICHINOSE JUN (JP)
ICHIKAWA HIROAKI (JP)
IMAI TOMOYUKI (JP)
NAGATSU KOTARO (JP)
SUZUKI HISASHI (JP)
Application Number:
PCT/JP2022/000116
Publication Date:
July 14, 2022
Filing Date:
January 05, 2022
Export Citation:
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Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECH (JP)
International Classes:
G21G4/08
Domestic Patent References:
WO2021002275A12021-01-07
Foreign References:
JP2009527731A2009-07-30
JP2017538780A2017-12-28
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
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