Title:
PRODUCTION METHOD OF MULTIPLE REGENERATED HAIR FOLLICLE PRIMORDIA, PRODUCTION METHOD OF HAIR FOLLICLE TISSUE-CONTAINING SHEET, HAIR REGENERATION KIT AND METHOD FOR SCREENING HAIR GROWTH PROMOTER OR HAIR GROWTH INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/039376
Kind Code:
A1
Abstract:
A production method of multiple regenerated hair follicle primordia, said method comprising a step for inoculating a microwell plate, which is provided with regularly-arranged minute depressions, simultaneously with mesenchymal cells and epithelial cells, and then co-culturing the mesenchymal cells and the epithelial cells with the use of a fibroblast growth factor-containing medium while supplying oxygen at least from the upper surface and bottom surface of the microwell plate to these cells so as to form hair follicle primordia within the minute depressions. The microwell plate is formed of an oxygen permeable material. A hair regeneration kit which comprises a microwell plate provided with regularly-arranged minute depressions and a fibroblast growth factor, wherein the microwell plate is formed of an oxygen permeable material.
Inventors:
FUKUDA JUNJI (JP)
KAGEYAMA TATSUTO (JP)
SHIMIZU AKIHIRO (JP)
KAGEYAMA TATSUTO (JP)
SHIMIZU AKIHIRO (JP)
Application Number:
PCT/JP2018/030410
Publication Date:
February 28, 2019
Filing Date:
August 16, 2018
Export Citation:
Assignee:
NAT UNIV CORP YOKOHAMA NAT UNIV (JP)
International Classes:
C12N5/071; C12Q1/02
Domestic Patent References:
| WO2017073625A1 | 2017-05-04 | |||
| WO2012115079A1 | 2012-08-30 | |||
| WO2016039278A1 | 2016-03-17 | |||
| WO2012042618A1 | 2012-04-05 |
Foreign References:
| JP2017201979A | 2017-11-16 |
Other References:
KAGEYAMA TATSUTO, FUKUDA JUNJI: "Cell culture plate for hair regeneration using micro-machining", TEXTILE PROCESSING TECHNOLOGY, vol. 51, no. 11, 2016, pages 36 - 41
Attorney, Agent or Firm:
SHIGA INTERNATIONAL PATENT OFFICE (JP)
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